Silylated Erythromycin Oxime Ketal

CAS: 119665-76-8

Ref. TR-S435040

Información del producto

• Nombre: Silylated Erythromycin Oxime Ketal
• Sinónimos: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-trimethylsilyloxyoxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-trimethylsilyloxyoxan-2-yl]oxy-10-(2-methoxypropan-2-yloxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one, Silylated, (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-({4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl}oxy)-14-ethyl-7,12,13-trihydroxy-4-({4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl}oxy)-10-{[(2-methoxypropan-2-yl)oxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one (non-preferred name)

Descripción

Applications Silylated Erythromycin Oxime Ketal is a useful intermediate in the synthesis of acylide derivatives with antibacterial properties from erythromycin A.
References Xu, P., et al.: Bioorg. Med. Chem. Lett., 17, 3330 (2007), Liang, J., et al.: Gaodeng Xuexiao Huaxue, 28, 481 (2007)

• Marca: TRC

Propiedades químicas

• Peso molecular: 965.409
• Fórmula: C₄₇H₉₂N₂O₁₄Si₂
• Color/Forma: Neat
• InChI: InChI=1S/C47H92N2O14Si2/c1-23-34-47(12,53)39(50)29(4)36(48-63-44(8,9)54-15)27(2)25-45(10,52)40(60-43-38(61-64(17,18)19)33(49(13)14)24-28(3)56-43)30(5)37(31(6)42(51)58-34)59-35-26-46(11,55-16)41(32(7)57-35)62-65(20,21)22/h27-35,37-41,43,50,52-53H,23-26H2,1-22H3/b48-36+/t27-,28-,29+,30+,31-,32+,33+,34-,35+,37+,38-,39-,40-,41+,43+,45-,46-,47-/m1/s1
• Clave InChI: InChIKey=GAYMGJQYVVDZLC-IJIYICMKSA-N
• SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O[Si](C)(C)C)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O[Si](C)(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OC(C)(C)OC)[C@H](C)[C@@H](O)[C@]1(C)O