Sodium (3R,5S)-5-(6-Cyclopropyl-10-fluorobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoate

CAS: 1187966-93-3

Ref. TR-S644840

Información del producto

• Nombre: Sodium (3R,5S)-5-(6-Cyclopropyl-10-fluorobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoate
• Sinónimos: [(3R,5S)-5-(6-cyclopropyl-10-fluorobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoyl]oxysodium
• Marca: TRC

Descripción

Applications Sodium (3R,5S)-5-(6-cyclopropyl-10-fluorobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoate is an impurity of pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase. Antilipemic.
References Grobelny, P., et. al.: J. Pharmaceut. Biomed. Anal., 50, 597 (2009); Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997); Yamada, I., et al.: Xenobiotica, 33, 789 (2003); Park, S., et al.: Clin. Ther., 27, 1074 (2005)

Propiedades químicas

• Peso molecular: 441.427
• Fórmula: C₂₅H₂₁FNNaO₄
• Color/Forma: Neat
• InChI: InChI=1S/C25H22FNO4.Na/c26-14-7-8-16-18(9-14)19(22(29)10-15(28)11-23(30)31)12-20-24(16)17-3-1-2-4-21(17)27-25(20)13-5-6-13;/h1-4,7-9,12-13,15,22,28-29H,5-6,10-11H2,(H,30,31);/q;+1/p-1/t15-,22+;/m1./s1
• Clave InChI: InChIKey=XZPFMVDCGZBIAB-GYOOIPBJSA-M
• SMILES: O=C(C[C@H](O)C[C@H](O)c1cc2c(C3CC3)nc3ccccc3c2c2ccc(F)cc12)O[Na]