N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt

CAS: 17388-80-6

Ref. TR-S688790

Información del producto

• Nombre: N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt
• Sinónimos: N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic acid disodium salt, N-(5-Amino-1-ribosyl-4-imidazolecarbonyl)-L-aspartic acid disodium salt, N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic acid disodium salt, Acadesi

Descripción

Applications A metabolite of Purine. Purine metabolism by adenylosuccinasedeficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

• Marca: TRC

Propiedades químicas

• Peso molecular: 418.267
• Fórmula: C₁₃H₁₆N₄Na₂O₉
• Color/Forma: Neat
• InChI: 2*+1/p-2/t4-,5+,8+,9+,12+, , /m0../s1, /q, /h3-5,8-9,12,18,21-22H,1-2,14H2,(H,16,23)(H,19,20)(H,24,25), , InChI=1S/C13H18N4O9.2Na/c14-10-7(11(23)16-4(13(24)25)1-6(19)20)15-3-17(10)12-9(22)8(21)5(2-18)26-12,
• Clave InChI: InChIKey=ZZPKVAPCMROQPH-KGBHUAOWSA-L
• SMILES: Nc1c(C(=O)N[C@@H](CC(=O)O[Na])C(=O)O[Na])ncn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O