Sulindac Sulfide

CAS: 49627-27-2

Ref. TR-S699220

Información del producto

• Nombre: Sulindac Sulfide
• Sinónimos: (Z)-2-{5-Fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid, Sulindac Sulphane, Sulindac Related Compound C, Sulindac Impurity C, (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid, (Z)-Sulindac sulfide, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-, 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-, Sulindac sulfide, Sulindac sulfide, (Z)-, cis-Sulindac sulfide

Descripción

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP.
References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),

• Marca: TRC

Propiedades químicas

• Peso molecular: 340.41
• Fórmula: C₂₀H₁₇FO₂S
• Color/Forma: Yellow-Orange
• InChI: InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
• Clave InChI: InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
• SMILES: CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1