TG101348

CAS: 936091-26-8

Ref. TR-T337905

Información del producto

• Nombre: TG101348
• Sinónimos: N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide, Benzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]-, Fedratinib, Inrebic, Sar 302503, TG101348 HCl, Tg 101348, Tg 10138, Tg101348
• CAS: 936091-26-8

Descripción

Applications TG101348 is a selective inhibitor of JAK2 tyrosine kinase. Potent JAK2 inhibitor.
References Rosenthal, A., et al.: Expert Opin. Pharmacotherapy, 15, 1265 (2014); Geyer, H.L., et al.: Hematol., 17, s129 (2012); Zhou, T. et al.: Leukemia, 28, 404 (2014)

• Marca: TRC

Propiedades químicas

• Peso molecular: 524.68
• Fórmula: C₂₇H₃₆N₆O₃S
• Color/Forma: White To Off-White
• InChI: InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
• Clave InChI: InChIKey=JOOXLOJCABQBSG-UHFFFAOYSA-N
• SMILES: Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1