Entre las marcas de nuestros más de 25 colaboradores destaca TargetMol

<p>(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.</p>

<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>

<p>N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine serves as a PEGn linker for antibody-drug conjugates (ADC).</p>

<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>

<p>MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate that forms part of the antibody-antibiotic conjugate (AAC) molecule. It is synthesized by conjugating the linker with the antibiotic Gemcitabine. This compound is useful in studying the immunotherapy of bacterial infections and developing novel antibacterial drugs.</p>

<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>

<p>Boc-L-Cys(Propargyl)-OH (DCHA) is a reagent utilized in click chemistry and can be applied in various biochemical studies.</p>

(2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) is a click chemistry reagent containing azide groups. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with molecules that have alkyne groups. Additionally, it can partake in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

<p>Boc-Ser(O-propargyl)-OH (DCHA) is a click chemistry reagent containing a propargyl group.</p>

<p>(S)-N3-HABA (DCHA) is a reagent used in click chemistry, notable for its application in bonding nucleic acids, lipids, proteins, and other molecules due to its high yield, specificity, and simplicity. This compound contains an Azide group, enabling a copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC) with molecules that have an Alkyne group, as well as a Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.</p>

DAPOA DCHA, a compound containing azide groups, serves as a pivotal chemical reagent. It is utilized in peptide synthesis as a linker and can be further modified via the Staudinger ligation or click chemistry on azide groups. This compound acts as a building block for dendritic structures. It engages in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups and undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing DBCO or BCN groups.

<p>H-L-Dbu(N3)-OH is a click chemistry reagent that contains an azide group. Click chemistry has significant potential for applications in the coupling of nucleic acids, lipids, proteins, and other molecules due to its beneficial features such as high yield, high specificity, and simplicity. This compound can react with molecules containing alkyne groups via copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.</p>

<p>MeO-PEG-alkyne (MW 750Da) is a click chemistry reagent that includes an alkyne group. It possesses an azide group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.</p>

<p>Me-PMeOx(100)-N3 (MW 8.5kDa) is a reagent utilized in click chemistry, which offers significant potential for joining nucleic acids, lipids, proteins, and other molecules. Valued for its high yield, specificity, and simplicity, it sees widespread application in various research fields. Equipped with an Azide group, it can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group. Additionally, it participates in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.</p>

<p>Adenosine 5′-O-(1-thiotriphosphate) (disodium) is an adenosine nucleotide modified at the alpha-phosphate.</p>

<p>pppApA sodium is a linear dinucleotide intermediate involved in the enzymatic production of bacterial signaling nucleotide c-diAMP. It is formed by the linkage of two ATP molecules.</p>

<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>

<p>Carbonic anhydrase inhibitor18 (Compound 9) is an inhibitor of human carbonic anhydrase (hCA) isozymes, with Ki values of 604.8 nM for hCA I, 333.6 nM for hCA II, 1.9 nM for hCA IX, and 6.7 nM for hCA XII. Carbonic anhydrase inhibitor18 is applicable in cancer research.</p>

<p>hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.7 μM for both isoforms. This compound is applicable in cancer research.</p>

Butyryl-Coenzyme A (trisodium) is a microbial metabolite that can be synthesized into butyric acid or butyrate.

Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.

AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.