Entre las marcas de nuestros más de 25 colaboradores destaca TargetMol

PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).

Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.

<p>FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).</p>

FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).

Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)

Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.

<p>Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.</p>

Dihomo-γ-linolenic acid (DGLA) has antitumor and antiproliferative effects and inhibits the growth of xenograft tumor cells.

<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>

<p>Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity.</p>

Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.

MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).

Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).

<p>Melittoside: phenolic glycoside with antioxidant, anti-inflammatory, antifungal properties; researched for cancer, diabetes, heart disease treatment.</p>

Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).

Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.

Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.

<p>D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ.</p>

<p>27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.</p>

LysoPC(14:0/0:0) is a lysophospholipid (LyP) and mono-glycerophospholipid.

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T

<p>Pralsetinib (BLU-667) is a potent RET inhibitor targeting WT, V804L/M, M918T, and fusion mutants (IC50: 0.3-0.4 nM).</p>

Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.

Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).

<p>Avosentan（Ro 67-0565; SPP-301） is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.</p>

<p>RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.</p>

<p>Hydroxyphenyllactic acid is an antifungal metabolite, fungi such as Lactobacillus sp. SK007.</p>

Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.

Spaglumic acid acetate (Isospaglumic acid acetate) is a neuropeptide found in millimolar concentrations in brain.

MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).

Chrysin-7-O-glucuronide (Chrysin 7-O-beta-D-glucopyranuronoside) is a natural product, with antioxidant activity

Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

<p>ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.</p>

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous

Grapiprant (AAT-007) is a selective EP4 receptor antagonist.

AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).

<p>Coumestrol in soybeans inhibits ES2 cell growth (IC50: 50 μM) and combats neurological issues, cancer, and autoimmunity.</p>

N-Nornuciferine, an aporphine alkaloid from lotus leaf, inhibits CYP2D6, shows high oral bioavailability, rapidly crosses the BBB, and exhibits prolonged systemic exposure.

N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50:

Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.

Fagomine (D-Fagomine) is a glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ), with hypoglycemic activity.

<p>Exalamide (2-(Hexyloxy)benzamide) is an aromatic amide with antifungal activity used in the study of dermatophytes.</p>

<p>Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).</p>

Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.

Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer.

Metixene HCl hydrate is a potential anticholinergic for Parkinson's with IC50 of 55 nM and Ki of 15 nM against muscarine receptors.

CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).

<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>

<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>

<p>Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.</p>

Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).

<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>

<p>GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).</p>

Sphingomyelin is a natural sphingolipid that existed in animal cell membranes. It implicates the regulation of transmembrane signaling.

NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).

EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).

Tandospirone (SM-3997) is a 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity used in the study of central nervous system disorders.

<p>Ingenol-5,20-acetonide-3-O-angelate (Ingenol 5,20-acetonide 3-angelate) is a natural product.</p>

R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.

<p>Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.</p>

'ARRY 520 hydrochloride: a KSP inhibitor causing apoptosis and strong anti-proliferative effects.'

BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).

Type III collagen (from bovine skin) is a collagen protein capable of stimulating the immune system in animals to generate specific antibodies against it. Additionally, this collagen serves as a hydrolytic substrate for matrix metalloproteinases (MMPs).

Advanced glycation end products are the outcome of non-enzymatic glycation reactions involving biomolecules such as proteins, lipids, reducing sugars.

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, transporting oxygen from the lung to tissue.

Low-density lipoprotein (human) is one of the five main lipoproteins responsible for transporting cholesterol to various tissues such as the adrenal glands, gonads, muscle, and adipose tissue.

Submandibular mucin is a high molecular weight glycoprotein that serves as a substrate for viral neuraminidase enzymes.

Oxidized low density lipoprotein (mouse) is a modified form of low-density lipoprotein (LDL). It induces atherosclerosis (AS) by promoting endothelial dysfunction and accelerating the growth and migration of vascular smooth muscle cells (VSMCs).

<p>PorcineFactor Xa is obtained by activating purified Porcine Factor X using Russells' Viper Venom, after which the venom is removed.</p>

<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>

<p>Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.</p>

<p>O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.</p>

Osteocalcin, bovine is a vitamin K-dependent bone-specific protein, also known as bone gamma-carboxyglutamate protein (BGLAP). It is a small (49 amino acids) non-collagenous hormone.

Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end.

<p>α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TIM). This compound is employed to measure transketolase (TK) activity in erythrocyte hemolysates, which helps in assessing vitamin B deficiency.</p>

<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>

SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.

<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>

<p>Sortase A, S. aureus (SrtA) is found in many Gram-positive bacteria and facilitates the recruitment of cell surface proteins. It plays a crucial role in the attachment of various molecules on the cell surface.</p>

ST8 alpha-2,8-Sialyltransferase 4 (ST8SIA4) is a sialyltransferase enzyme involved in the sialylation process. It is also associated with breast cancer progression, facilitating cancer cell proliferation and invasion in a sialyltransferase-dependent manner.

AMK318 (Immobilized cephalexin acylase) is a biocatalyst and a critical enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions (such as low or high pH). By incorporating stimulus responsiveness into these enzyme modifications, dynamic control of activity becomes feasible.

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.

Aspartate Aminotransferase, Human is a biocatalyst and serves as a pivotal enzyme in new biotechnology. Enzyme engineering aims to improve the reaction kinetics, substrate specificity, and activity under extreme conditions (such as low or high pH). By introducing stimuli-responsive modifications to these enzymes, the dynamic regulation of activity can also be achieved.

<p>N-Acetylgalactosaminyltransferase 4 (GALNT4) is a glycosyltransferase capable of inhibiting the activation of ASK1. It functions by directly binding to ASK1, preventing N-terminal dimerization and subsequent phosphorylation. This interaction leads to significant inactivation of downstream JNK/p38 and NF-κB signaling, thereby improving the prognosis of liver surgery.</p>

<p>ST6Sialyltransferase5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers sialic acid to N-acetylgalactosamine (GalNAc) residues. It may serve as a biomarker in cervical screening samples.</p>

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

Creatine Kinase BB (CK-BB) Isoenzyme, derived from Porcine Brain (also known as CPK-1, CKBB isoenzyme, CK-BB), serves as a valuable biological material or organic compound for life science research.

Phosphoglucose isomerase, bacillus stearothermophilus, is a highly conserved glycolytic enzyme and dimerase. It catalyzes the isomerization of glucose-6-phosphate into fructose-6-phosphate.

HumanFactor VIIa is a vitamin K-dependent serine protease involved in the blood coagulation process. It has the ability to activate coagulation factor X, which in turn converts prothrombin into thrombin, leading to the transformation of fibrinogen into fibrin and resulting in the formation of blood clots. HumanFactor VIIa holds potential for improving hemophilia.

Tte UvrD Helicase is a thermostable UvrD helicase initially isolated from Thermoanaerobacter tengcongensis. This enzyme can unwind DNA duplexes that have 3' or 5' single-stranded DNA tails, as well as DNA substrates with blunt ends.

Recombinant Trypsin is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine.

dsDNase is a highly specific endonuclease for double-stranded DNA (dsDNA) that can rapidly and efficiently eliminate contaminant DNA from PCR master mixes.

C1qProtein (Cyno) is a subunit of the complement system. It recognizes various ligands and is involved in maintaining immune system balance, promoting tissue repair, and defending against pathogens.