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VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.

Rf470 (Rotor NO.4) TFA is an FMR-probe-D-lysine conjugate (Max Ex: 470 nM; Max Em: 640 nM) that can be covalently integrated into bacterial peptidoglycan. In its free state, Rf470 TFA exhibits weak fluorescence, which significantly increases upon integration into peptidoglycan by transpeptidase catalysis. This fluorescence change allows Rf470 TFA to be used for real-time monitoring of peptidoglycan biosynthesis, detecting transpeptidase activity, and screening antibiotics.

Decylene glycol, an antimicrobial in cosmetics, alters liposome membrane fluidity.

Bupirimate, a systemic fungicide for powdery mildew in roses and apples, belongs to pyrimidines.

SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.

<p>Decane-1,10-dithiol is used as an important raw material and intermediate in organic synthesis, agrochemicals and pharmaceuticals.</p>

T-01-C7-amide is an E3 ligase ligand-linker conjugate (E3 ligase Ligand-linker conjugate) employed in the synthesis of PROTAC BRD4 Degrader-36.

MI1013 is a PROTAC PXR degrader with a DC50 of 89 nM and a Dmax of 82%. It degrades PXR in human liver cancer RG cells (HepaRG) and modulates CYP3A4 promoter activity with specificity and safety through PXR degradation. MI1013 influences key genes involved in sulfate conjugation (e.g., SULT1E1), bile acid synthesis (CYP7A1), gluconeogenesis (PCK1), ketogenesis (HMGCS20), and hepatocyte proliferation (MKI67).

<p>Benzene, 1,3-dichloro-5-nitro- is a bioactive chemical.</p>

Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM). It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.

APH02174 is a highly selective and orally active IRAK4PROTAC degrader, with a DC50 of 4.01 nM in THP-1 cells. It blocks inflammatory signaling by inhibiting IL-6 release and is applicable for researching inflammatory diseases such as psoriasis and rheumatoid arthritis.

KRASG12D-IN-6 is a PROTAC target protein ligand used in the synthesis of CH091138. CH091138 is a potent and selective KRASG12D PROTAC degrader with anti-tumor activity.

Benzene, 1,3-diiodo- is a bioactive chemical.

Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative with antifungal activity against various plant pathogenic fungi. It has an EC50 of 0.338 μg/mL against Botrytis cinerea. The compound works by targeting β-tubulin, disrupting hyphal morphology, and affecting cell membrane permeability, while posing low ecological risk.

1,3-Diisopropenylbenzene is a bioactive chemical.

KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and an ethyl ester prodrug of compound 7b. Inside cells, KMT9-IN-1 releases the active form 7b through the action of esterases. It specifically associates with the KMT9 target within cells, leading to a reduction in H4K12me1 levels. KMT9-IN-1 exhibits antitumor activity against colon cancer and can be employed in research on prostate cancer and hepatocellular carcinoma.

VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.

<p>Troleandomycin is a macrolide antibiotic and is similar to Erythromycin.</p>

PROTACEGFRdegrader 14 is a potent and selective EGFR PROTAC degrader with a DC50 value of approximately 2.9 nM against EGFRL858R/T790M/C797S and a Dmax of 93.1%. It induces the selective degradation of EGFRC797S via a VHL and proteasome-dependent mechanism, downregulating EGFR-related transcriptomes. PROTACEGFRdegrader 14 exhibits high selectivity for EGFRWT, induces cell cycle arrest and apoptosis, and effectively inhibits tumor growth. It is applicable for research on non-small cell lung cancer (NSCLC).

Decanedinitrile is a biochemical.