CAS 1007306-20-8

Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp trifluoroacetate salt

CAS : 1007306-20-8

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Formule : C₄₂H₅₈N₁₂O₁₆

Degré de pureté : Min. 95%

Masse moléculaire : 986.98 g/mol

Ref: 3D-FA110977

Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp

CAS : 1007306-20-8

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).

Formule : C₄₂H₅₈N₁₂O₁₆

Degré de pureté : 98.2%

Masse moléculaire : 986.99

Ref: 01-4045326