CAS 1007358-76-0

Ambrisentan R-Enantiomer ((R)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid)

CAS : 1007358-76-0

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formule : C₂₂H₂₂N₂O₄

Couleur et forme : White Fine Powder

Masse moléculaire : 378.15796

Ref: 45-1019188

(R)-Ambrisentan

CAS : 1007358-76-0

Formule : C₂₂H₂₂N₂O₄

Couleur et forme : White To Off-White Solid

Masse moléculaire : 378.43

Ref: 4Z-A-315

Avatrombopag Impurity 30

CAS : 1007358-76-0

Formule : C₁₆H₂₁Cl₂N₃O

Couleur et forme : White To Off-White Solid

Masse moléculaire : 342.26

Ref: 4Z-A-315032

Avatrombopag Impurity 28

CAS : 1007358-76-0

Formule : C₁₄H₈Cl₂N₄S₄

Couleur et forme : White To Off-White Solid

Masse moléculaire : 431.39

Ref: 4Z-A-315030

(R)-Ambrisentan

CAS : 1007358-76-0

Applications (R)-Ambrisentan is the R-isomer impurity of Ambrisentan (A575860), which is a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996); Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002); Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003);

Formule : C₂₂H₂₂N₂O₄

Couleur et forme : White To Off-White

Masse moléculaire : 378.42

Ref: TR-A575873

(R)-Ambrisentan

CAS : 1007358-76-0

(R)-Ambrisentan is an endothelin receptor antagonist, which is a pharmacological agent derived synthetically to target and inhibit specific cellular pathways. It is primarily utilized in the treatment of pulmonary arterial hypertension (PAH), where it plays a crucial role in modulating vascular function. The mode of action of (R)-Ambrisentan involves selective antagonism of the endothelin type A (ETA) receptors, which are responsible for vasoconstriction and proliferation of vascular smooth muscle cells. By blocking these receptors, it mitigates the effects of endothelin, a potent vasoconstrictor, thus reducing blood pressure and improving blood flow in pulmonary arteries.

Formule : C₂₂H₂₂N₂O₄

Degré de pureté : Min. 95%

Masse moléculaire : 378.40 g/mol

Ref: 3D-HQB35876

Ambrisentan (R)-Isomer

CAS : 1007358-76-0

Formule : C₂₂H₂₂N₂O₄

Masse moléculaire : 378.43

Ref: ST-EA-CP-A15015