CAS 1046447-90-8

JNJ-39758979

CAS : 1046447-90-8

JNJ-39758979: selective H4 receptor antagonist, Kis 12.5/5.3/25 nM (human/mouse/monkey), blocks histamine cAMP inhibition (pA2 7.9).

Formule : C₁₁H₁₉N₅

Degré de pureté : 98.33% - 99.62%

Couleur et forme : Solid

Masse moléculaire : 221.3

Ref: TM-T11723L

JNJ-39758979

CAS : 1046447-90-8

JNJ-39758979

Degré de pureté : ≥98%

Masse moléculaire : 221.3g/mol

Ref: 54-BUP12890

JNJ 39758979 TFA Salt

Produit contrôlé

CAS : 1046447-90-8

Applications JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.
References Savall, B. M. et al.: J Med Chem. 2014 Mar 27;57(6):2429-39;

Formule : C₁₁H₁₉N₅·xC₂HF₃O₂

Couleur et forme : Neat

Masse moléculaire : 221.30 + x(114.2)

Ref: TR-J212500

JNJ 39758979

CAS : 1046447-90-8

JNJ 39758979 is a small molecule compound, which is a selective antagonist of the P2X7 receptor. This receptor is a purinergic ligand-gated ion channel sourced from human and mammalian cell lines, prominent in neurobiological and immunological tissues. The mode of action involves the inhibition of the P2X7 receptor, which plays a crucial role in inflammatory processes and cell death signaling pathways. By blocking this receptor, JNJ 39758979 reduces the release of pro-inflammatory cytokines, thus modulating neuroinflammation.

Formule : C₁₁H₁₉N₅

Degré de pureté : Min. 95%

Masse moléculaire : 221.3 g/mol

Ref: 3D-WRB44790