CAS 11061-68-0
:insuline humaine
Description :
insuline humaine, avec le numéro CAS 11061-68-0, est une hormone peptidique produite par le pancréas qui joue un rôle crucial dans le métabolisme du glucose. Elle est composée de 51 acides aminés et a un poids moléculaire d'environ 5 800 daltons. L'insuline fonctionne principalement pour abaisser les niveaux de glucose dans le sang en facilitant l'absorption du glucose dans les cellules, en particulier dans les tissus musculaires et adipeux, et en inhibant la production hépatique de glucose. La structure de l'insuline se compose de deux chaînes, A et B, liées par des liaisons disulfure, qui sont essentielles à son activité biologique. L'insuline est généralement administrée par injection en raison de sa nature protéique, car elle n'est pas efficace lorsqu'elle est prise par voie orale en raison de sa dégradation dans le tractus gastro-intestinal. Elle est utilisée thérapeutiquement dans la gestion du diabète sucré, aidant à contrôler les niveaux de sucre dans le sang chez les individus présentant une carence ou une résistance à l'insuline. insuline humaine est produit par la technologie de l'ADN recombinant, garantissant un approvisionnement constant et sûr pour un usage médical.
Formule :C257H383N65O77S6
InChI :InChI=1/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134?,135?,136?,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1
Synonymes :- Insulin, Zinc, Human, Recomb.
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
14 produits concernés.
Insulin solution (4mg/mL) [Optimized for Cell Culture]
CAS :Couleur et forme :Colorless to Almost colorlessclear liquidInsulin Human
CAS :Insulin and its saltsFormule :C257H383N65O77S6Couleur et forme :White Lyophilized CakeMasse moléculaire :5803.63765High Molecular Weight Insulin Human
CAS :Insulin and its saltsFormule :C257H383N65O77S6(monomer)Couleur et forme :White Off-White PowderMasse moléculaire :5803.63765Insulin Human, recombinant
CAS :Formule :C257H383N65O77S6Degré de pureté :95.0 - 105.0 % (dried basis)Couleur et forme :White to off-white powderMasse moléculaire :5807.57Insulin (human)
CAS :Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood.Formule :C257H383N65O77S6Degré de pureté :97.32% - 99.99%Couleur et forme :SolidMasse moléculaire :5807.57Insulin (Human)
CAS :Applications Insulin (Human) is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.
References Lai, Y. et al.: Biochem. J., 460, 363 (2014); Hedman, C. et al.: Clin. Endocrinol., 81, 58 (2014);Formule :C257H383N65O77S6Couleur et forme :NeatMasse moléculaire :5807.57Insulin (Human)
CAS :Insulin is a peptide hormone that regulates the uptake and storage of glucose by muscle and fat cells. Insulin is produced by beta cells in the pancreas, which release it into the bloodstream when blood sugar levels rise. Insulin lowers glucose levels by increasing the amount of glucose taken up from the blood into muscle and fat cells, suppressing hepatic gluconeogenesis, and promoting glycolysis. It also increases protein synthesis, decreases proteolysis, and stimulates growth. With a molecular weight of 5808 Da, insulin is composed of two polypeptide chains with an approximate molecular weight of 3120 Da each linked by disulfide bonds. Insulin has no lipid moiety or carbohydrate moiety.
Insulin binds to its receptor on the surface of a cell to trigger one or more signaling cascades leading to changes in metabolism. Binding to the receptor triggers a conformational change in the receptor that causes insulin to be released from its binding site on the receptor.Formule :C257H383N65O77S6Degré de pureté :Min. 95%Masse moléculaire :5,807.6 g/molInsulin
CAS :Insulin is a hormone that is produced by beta cells in the pancreas and regulates blood sugar levels. It is used for the treatment of diabetes mellitus, a disease in which the body does not produce enough insulin or cannot use insulin properly. Insulin works by lowering the level of glucose (sugar) in the blood, thereby regulating its supply to various parts of the body. Insulin has been shown to be effective at reducing postprandial blood glucose concentrations. This drug also lowers blood glucose concentrations by stimulating glucose uptake into muscle and adipose tissue. Insulin is also used to treat type 1 diabetes, gestational diabetes, and other conditions where low insulin production results in high blood sugar levels.Formule :C257H383N65O77S6Degré de pureté :Reported (%)Couleur et forme :PowderMasse moléculaire :5,807.57 g/molInsulin (Human)
CAS :Human insulin is a peptide hormone produced by beta cells in the pancreas. The insulin receptor is found on the surface of liver, fat, and muscle cells. When binding to its receptor, insulin opens ion channels allowing potassium ions to flow into the cell and sodium ions to flow out of the cell. This change in ion concentration causes an electrical potential across the membrane that triggers an influx of calcium ions from outside the cell. These changes result in an increase in glucose uptake by tissues and inhibition of glucose production by the liver. Insulin also binds to a secondary receptor called IGF-1R (insulin-like growth factor) which activates intracellular signaling pathways involving PI3K and Akt kinase. Insulin can be used as a research tool for studying protein-protein interactions or as a pharmacological agent for diabetes treatment. This product is enzymatically derived from Porcine Insulin A-chain, available as a 0.5mg vial and contains disulfide bonds between CysA6-CysA11,CysA7-CysB7, and CysA20-CysB19.Formule :C257H383N65O77S6Degré de pureté :Min. 95%Masse moléculaire :5,807.6 g/molr-Insulin ex. Human for cell culture, 25 USP U/mg, Endotoxin (BET) 1.0EU/mg
CAS :Formule :C257H383N65O77S6Couleur et forme :White, PowderMasse moléculaire :~ 5808Insulin Human (COLD SHIPMENT REQUIRED) (DISCONTINUED)
CAS :Insulin and its saltsFormule :C257H383N65O77S6Couleur et forme :White CrystalsMasse moléculaire :5803.63765
![Insulin solution (4mg/mL) [Optimized for Cell Culture]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3B%2Fthumb%2FI1257.jpg&w=3840&q=75)
