CAS 1160295-21-5

MLN4924 hydrochloride

CAS : 1160295-21-5

Formule : C₂₁H₂₆ClN₅O₄S

Degré de pureté : 95%

Masse moléculaire : 479.9802

Ref: IN-DA008TIB

Pevonedistat hydrochloride

CAS : 1160295-21-5

Pevonedistat hydrochloride

Degré de pureté : ≥98%

Masse moléculaire : 479.98g/mol

Ref: 54-BUP21333

Pevonedistat hydrochloride

CAS : 1160295-21-5

Pevonedistat(MLN4924) hydrochloride is a NEDD8-activating enzyme inhibitor that induces apoptosis and can be used in the study of acute myeloid leukemias.

Formule : C₂₁H₂₆ClN₅O₄S

Degré de pureté : 98.44% - 99.19%

Couleur et forme : Solid

Masse moléculaire : 479.98

Ref: TM-T16117

Pevonedistat hydrochloride

CAS : 1160295-21-5

Pevonedistat is a sulfamate, dihydro, nedd8-activating enzyme inhibitor that has been shown to inhibit the activity of NEDD8. Pevonedistat is used in cancer chemotherapy and prevents methylation of DNA by inhibiting the activity of enzymes that activate NEDD8. Pevonedistat has also been shown to be a marker for mesenchymal stem cells and can be used to differentiate between these cells and other types of cells. The drug binds to sulfamic acid, an enzyme inhibitor, and blocks the conversion of hypomethylated cytosine into methylcytosine. This causes hypomethylation, which leads to DNA damage. Hypomethylation also leads to mutations in cancer cells, making them more susceptible to death by chemotherapeutic agents such as 5-fluorouracil or cisplatin.

Formule : C₂₁H₂₆ClN₅O₄S

Degré de pureté : Min. 95%

Masse moléculaire : 479.98 g/mol

Ref: 3D-KWB29521