CAS 1226499-97-3

N-(4-Chloro-2-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine

Produit contrôlé

CAS : 1226499-97-3

Applications N-(4-Chloro-2-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine is an intermediate in the synthesis of 5-((2-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide Hydrochloride (D474433) which is an impurity of Pazopanib (P210925), which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

Formule : C₁₃H₁₂ClN₅

Couleur et forme : Neat

Masse moléculaire : 273.72

Ref: TR-C472230