CAS 1229591-56-3

UCPH-102

CAS : 1229591-56-3

UCPH-102 is a potent and selective inhibitor of acid transporter (AT) with a trimeric structure. It has been shown to inhibit glutamate release, synaptic function, and profile in vivo. UCPH-102 was found to be active in vivo with carboxy as the bioavailability enhancer and against human ATs. It is also an analog of UCPH-101 and it shows inhibitory activities against uptake of glutamate by rat brain synaptosomes with low bioavailability in vivo due to modifications on the molecule. UCPH-102 has been shown to be more potent than UCPH-101 in vitro and in vivo, with a lower Km for glutamate uptake inhibition, higher potency for inhibiting synaptic function, and better penetration into the brain than UCPH-101.

Formule : C₂₁H₁₈N₂O₂

Degré de pureté : Min. 95%

Masse moléculaire : 330.4 g/mol

Ref: 3D-EZB59156

UCPH-102

CAS : 1229591-56-3

UCPH-102: Selective EAAT1 inhibitor, IC50 0.43 μM, treats Alzheimer's, ALS, chronic pain, OCD; crosses blood-brain barrier, targets T-ALL cells.

Formule : C₂₁H₁₈N₂O₂

Couleur et forme : Solid

Masse moléculaire : 330.38

Ref: TM-T60966