CAS 124584-08-3

Peptide natriurétique cérébral-32 (humain)

Description :

Le peptide natriurétique cérébral (BNP) est une neurohormone principalement produite dans les ventricules cardiaques en réponse à l'expansion du volume ventriculaire et à la surcharge de pression. La forme spécifique connue sous le nom de peptide natriurétique cérébral-32 (humain) est un peptide de 32 acides aminés qui joue un rôle crucial dans l'homéostasie cardiovasculaire. Il fonctionne en favorisant la natriurèse, la diurèse et la vasodilatation, aidant ainsi à réguler la pression artérielle et l'équilibre des fluides. Le BNP est impliqué dans la physiopathologie de l'insuffisance cardiaque, et ses niveaux dans le sang peuvent servir de biomarqueur pour diagnostiquer et gérer cette condition. Le numéro CAS 124584-08-3 identifie ce peptide spécifique, qui se caractérise par sa taille relativement petite et sa séquence d'acides aminés spécifique qui le distingue des autres peptides natriurétiques. Son activité biologique est médiée par la liaison à des récepteurs spécifiques, entraînant divers effets physiologiques, y compris l'inhibition du système rénine-angiotensine-aldostérone. Dans l'ensemble, le BNP est significatif tant dans les contextes cliniques que de recherche, en particulier en cardiologie.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Synonymes :

• Natriureticfactor-32 (human brain clone lhBNP57)
• 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane,cyclic peptide deriv.
• 1: PN:US6028055 SEQID: 1 claimed protein
• 6: PN:US20090011997 SEQID: 4 claimed protein
• 83: PN: US20080153747 SEQID: 83 claimedprotein
• Human brain natriuretic factor-32
• Human brain natriuretic peptide-32
• L-Histidine,L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-a-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,cyclic (10?
• 26)-Disulfide
• Natriureticpeptide type-B
• Nesiritide

BNP-32 (human)

CAS : 124584-08-3

Bachem ID: 4095916.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : 97.9%

Couleur et forme : White

Masse moléculaire : 3464.09

Ref: 01-4095916

BNP-32 (human)

CAS : 124584-08-3

The secretion of the cardiac hormone BNP-32 is increased considerably in patients with congestive heart failure, successful medical treatment of this condition will result in a decrease. Yandle et al. described a method for determining hBNP in human plasma. Effects of hBNP infusion in humans have been described by Holmes et al and La Villa et al. BNP is an important biomarker in the diagnosis of heart diseases. Additionally, BNP-32 may act as a neuropeptide. BNP-32 exerts strong lipolytic effects in humans.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : 97.8%

Masse moléculaire : 3464.09

Ref: 01-4049848

BNP-32 (human)

CAS : 124584-08-3

The secretion of the cardiac hormone BNP-32 is increased considerably in patients with congestive heart failure, successful medical treatment of this condition will result in a decrease. Yandle et al. described a method for determining hBNP in human plasma. Effects of hBNP infusion in humans have been described by Holmes et al and La Villa et al. BNP is an important biomarker in the diagnosis of heart diseases. Additionally, BNP-32 may act as a neuropeptide. BNP-32 exerts strong lipolytic effects in humans.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : 97.2%

Couleur et forme : White

Masse moléculaire : 3464.09

Ref: 01-4016567

Nesiritide

CAS : 124584-08-3

Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 3464.04

Ref: TM-TP1208

Brain Natriuretic Peptide-32 human

CAS : 124584-08-3

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Masse moléculaire : 3464.03

Ref: 7W-GP2071

BNP-32 (Human)

CAS : 124584-08-3

BNP-32 is a peptide that has been shown to activate G-protein coupled receptors and ion channels. It is known to be an agonist of the receptor for bradykinin and vasoactive intestinal peptide, as well as the receptor for neurotensin, which is a member of the tachykinin family. BNP-32 can also inhibit ligand binding to some receptors, such as those for calcitonin gene-related peptide (CGRP) and substance P (SP). BNP-32 has been used as a research tool in cell biology and pharmacology.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : Min. 95%

Masse moléculaire : 3,464.05 g/mol

Ref: 3D-PBN-4212-V

BNP-32 human

CAS : 124584-08-3

This 32 amino acid peptide contains a 17 amino acid ring structure that is common to all natriuretic peptides. It is also called the brain natriuretic peptide (BNP) because it was first identified in porcine brain- however, the main source of this peptide is not the brain but the cardiac ventricle. This cardiac neurohormone is secreted from the ventricles in response to volume expansion and pressure overload. It has natriuretic and vasodilatory effects and suppresses the renin-angiotensin-aldosterone system.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Couleur et forme : Powder

Masse moléculaire : 3,463.8 g/mol

Ref: 3D-CRB1000505

BNP-32 (human)

CAS : 124584-08-3

Natriuretic; vasodilatory;diuretic; treats decompensated congestive hear failure

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 3,464.04 g/mol

Ref: 3D-FB110377

Nesiritide acetate

CAS : 124584-08-3

Nesiritide acetate is a man-made form of the natriuretic peptide hormone that is secreted by the heart. It is used to treat high blood pressure and congestive heart failure. Nesiritide acetate increases the amount of sodium and water excreted from the body, which reduces blood volume and lowers blood pressure. It also relaxes blood vessels, leading to lower blood pressure. This drug can also be used in diagnosis to assess levels of natriuretic peptides in the bloodstream. The typical therapeutic dose for this drug is 100 mcg/kg given intravenously over 30 minutes and then infusion at 0.01 mcg/kg/min for up to 24 hours. The dosage may be increased or decreased depending on the severity of symptoms or side effects experienced by the patient.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄•(C₂H₄O₂)x

Degré de pureté : Min. 95 Area-%

Couleur et forme : Powder

Masse moléculaire : 3,464.05 g/mol

Ref: 3D-FN41185

BNP-32 (human) hydrochloride

CAS : 124584-08-3

BNP-32 is a peptide hormone that regulates the volume of blood in the heart and lungs. It is used to diagnose congestive heart failure, and also as a treatment for decompensated congestive heart failure. When given as an intravenous infusion, BNP-32 reduces the levels of natriuretic peptides in the blood stream by increasing their breakdown in the kidneys. The disulfide bond between cysteine residues (Cys-Cys) is essential for its activity. BNP-32 has been shown to be effective against infectious diseases such as HIV, hepatitis C, and tuberculosis. It is also used in combination with other drugs to treat high blood pressure. This drug can be administered orally or intravenously and is biocompatible with human tissue because it is chemically stable and non-toxic at therapeutic doses.

Formule : C₁₄₃H₂₄₄N₅₀O₄₂S₄

Degré de pureté : Min. 95%

Masse moléculaire : 3,464.04 g/mol

Ref: 3D-FB110257