CAS 1254977-87-1

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

CAS : 1254977-87-1

Formule : C₂₂H₂₃F₃N₄

Degré de pureté : 99%

Masse moléculaire : 400.44

Ref: IN-DA00A0IV

JNJ-42153605

CAS : 1254977-87-1

JNJ-42153605

Degré de pureté : ≥95%

Masse moléculaire : 400.44g/mol

Ref: 54-BUP07384

JNJ-42153605

CAS : 1254977-87-1

JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).

Formule : C₂₂H₂₃F₃N₄

Degré de pureté : 97.25% - 98.57%

Couleur et forme : Solid

Masse moléculaire : 400.44

Ref: TM-T3451

JNJ-42153605

CAS : 1254977-87-1

JNJ-42153605 is a novel allosteric modulator of the NMDA receptor. It is an agonist at the MGLUR2 receptor and has been shown to have a long-term treatment effect in animal models. JNJ-42153605 has also been shown to be effective in clinical trials for the treatment of patients with major depressive disorder and schizophrenia. The onset latency of this drug is less than one hour and its effects last up to 24 hours. This drug binds to glutamate receptors, which are ionotropic receptors that mediate fast synaptic transmission. JNJ-42153605 acts as an allosteric modulator by binding to a site that is different from the agonist binding site, but near it. The binding of JNJ-42153605 at this site increases the affinity of glutamate for its receptor, leading to increased uptake and activation of ion channels. This leads to excitatory postsynaptic potentials (EPSPs) and

Formule : C₂₂H₂₃F₃N₄

Degré de pureté : Min. 95%

Masse moléculaire : 400.44 g/mol

Ref: 3D-EAC97787