CAS 1258494-60-8

(S)-5-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

CAS : 1258494-60-8

(S)-5-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Degré de pureté : 98%

Masse moléculaire : 391.43g/mol

Ref: 54-OR1073881

TH 1338

CAS : 1258494-60-8

TH 1338 is an anhydride that has been synthesized as a precursor to anticancer drugs. It is a camptothecin derivative and inhibits the proliferation of cancer cells. TH 1338 was found to inhibit the proliferation of human erythrocytes in vitro and also inhibited the growth of sarcoma 180 in vivo. Hyperproliferative diseases such as leukemia, lymphoma, and carcinomas are associated with abnormal cell division. The inhibiting effects of TH 1338 on cell replication may be due to its ability to bind to DNA gyrase, topoisomerase II, or topoisomerase IV enzymes, which are required for DNA replication. This binding prevents the formation of an enzyme-substrate complex required for DNA synthesis and cell division.

Formule : C₂₂H₂₁N₃O₄

Degré de pureté : Min. 95%

Masse moléculaire : 391.4 g/mol

Ref: 3D-IAC49460

TH1338

CAS : 1258494-60-8

TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.

Formule : C₂₂H₂₁N₃O₄

Degré de pureté : 98.77%

Couleur et forme : Solid

Masse moléculaire : 391.42

Ref: TM-T28959