CAS 1300037-86-8

Tapentadol O-β-D-glucuronide

CAS : 1300037-86-8

Ref: 7W-GC1337

Tapentadol O-b-D-Glucuronide

Produit contrôlé

CAS : 1300037-86-8

Applications A metabolite of Tapentadol (T007200).
References Terlinden, R., et al.: Eur. J. Drug Metab. Pharmacokinet., 32, 163 (2007), Tzschentke, T., et al.: J. Pharmacol. Exp. Ther., 323, 256 (2007), Wade, W., et al.: Clin. Ther., 31, 2804 (2009),

Formule : C₂₀H₃₁NO₇

Couleur et forme : Neat

Masse moléculaire : 397.46

Ref: TR-T007210

Tapentadol O-b-D-Glucuronide (1 mg/ml in Methanol)

Produit contrôlé

CAS : 1300037-86-8

Formule : C₂₀H₃₁NO₇

Couleur et forme : Colourless

Masse moléculaire : 397.46

Ref: TR-KIT0155

Tapentadol-d5 O-β-D-Glucuronide

Produit contrôlé

CAS : 1300037-86-8

Formule : C₂₀D₅H₂₆NO₇

Couleur et forme : Neat

Masse moléculaire : 402.493

Ref: TR-T007212

Tapentadol-²-D-glucuronide solution

Produit contrôlé

CAS : 1300037-86-8

Tapentadol is a centrally acting analgesic agent that binds to the µ-opioid receptor. Tapentadol is metabolized in the liver by glucuronidation and sulfation. Tapentadol 2-D-glucuronide is an active metabolite of tapentadol and exhibits a higher affinity for µ-opioid receptors than tapentadol. The clinical relevance of this metabolite has not been studied, but concentrations of tapentadol 2-D-glucuronide in plasma may be useful for monitoring therapeutic effects and for assessing side effects such as respiratory depression. It is believed that tapentadol 2-D-glucuronide binds to opioid receptors in the brain, spinal cord, and peripheral nervous system, which accounts for its analgesic properties. The clinical development of tapentadol was designed to assess its safety and efficacy in pediatric patients (ages 6–17 years). Plasma concentrations were measured using liquid chromatography

Formule : C₂₀H₃₁NO₇

Degré de pureté : Min. 95%

Masse moléculaire : 397.46 g/mol

Ref: 3D-ACC03786