CAS 135635-50-6

Deshydroxy Tarcolimus

Produit contrôlé

CAS : 135635-50-6

Applications Deshydroxy Tarcolimus is an impurity of Tacrolimus(F370000). Tacrolimus is an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)

Formule : C₄₄H₆₉NO₁₁

Couleur et forme : Neat

Masse moléculaire : 788.02

Ref: TR-D119880