CAS 138-14-7
:Méthanesulfonate de déférioxamine
Description :
Méthanesulfonate de déférioxamine est un agent chélateur principalement utilisé dans le traitement des conditions de surcharge en fer, telles que celles résultant de transfusions sanguines répétées chez des patients atteints de conditions comme la thalassémie ou la drépanocytose. C'est un composé soluble dans l'eau qui forme des complexes stables avec des ions ferriques, facilitant leur excrétion par l'organisme. La substance est dérivée de la bactérie *Streptomyces pilosus* et se caractérise par sa capacité à se lier sélectivement au fer, réduisant ainsi sa toxicité et prévenant les dommages aux organes. Méthanesulfonate de déférioxamine est généralement administré par voie sous-cutanée ou intraveineuse, et sa pharmacocinétique implique une distribution rapide et une excrétion rénale. Le composé est connu pour son profil de toxicité relativement faible, bien que les effets secondaires potentiels puissent inclure des réactions allergiques, des troubles gastro-intestinaux et des effets sur la vision en cas d'utilisation prolongée. Son efficacité dans la gestion de la surcharge en fer en a fait un agent thérapeutique essentiel dans les domaines de l'hématologie et de l'oncologie.
Formule :C25H48N6O8·CH4O3S
InChI :InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
Code InChI :InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES :S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O
Synonymes :- Ba 33112
- Butanediamide, N<sup>4</sup>-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N<sup>1</sup>-(5-aminopentyl)-N<sup>1</sup>-hydroxy-, methanesulfonate (1:1)
- Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
- DFX mesylate
- Deferoxamine B mesylate
- Deferoxamine Mesilate
- Deferoxamine methanesulfonate
- Deferrioxamine B methanesulfonate
- Deferrioxamine methanesulfonate
- Desferal
- Desferal mesylate
- Desferrioxamine B mesylate
- Desferrioxamine B methanesulfonate
- Desferrioxamine mesilate
- Desferrioxamine mesylate
- Desferrioxamine methanesulfonate
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
- NSC 644468
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)
- Voir plus de synonymes
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14 produits concernés.
Deferoxamine Mesylate
CAS :Formule :C25H48N6O8·CH4O3SDegré de pureté :>97.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :656.79Desferrioxamine mesilate
CAS :Desferrioxamine mesilateFormule :C27H56N6O14S2Couleur et forme :Off-WhiteMasse moléculaire :752.8953DEFEROXAMINE MESILATE CRS
CAS :DEFEROXAMINE MESILATE CRSFormule :C27H56N6O14S2Masse moléculaire :752.8953Deferoxamine Mesylate
CAS :Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugsFormule :C25H48N6O8·CH4O3SCouleur et forme :White PowderMasse moléculaire :656.34148Deferoxamine mesylate
CAS :Formule :C26H52N6O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :656.7897Deferoxamine Mesylate
CAS :Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79Deferoxamine mesylate
CAS :Deferoxamine mesylateFormule :C25H48N6O8·CH3SO3HDegré de pureté :By hplc: 99.0% by area (Typical Value in Batch COA)Couleur et forme : white solidMasse moléculaire :656.79g/molDesferrioxamine B mesylate
CAS :Formule :C25H48N6O8·CH4O3SDegré de pureté :≥ 98.0%Couleur et forme :White to almost white powderMasse moléculaire :656.79Deferoxamine Mesylate
CAS :Produit contrôléApplications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);Formule :C25H48N6O8·CH4O3SCouleur et forme :Off-WhiteMasse moléculaire :656.79Deferoxamine mesylate
CAS :Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011
Formule :C26H52N6O11SDegré de pureté :Min. 98.0 Area-%Masse moléculaire :656.79 g/molDeferoxamine mesylate
CAS :Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system. Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.Formule :C26H52N6O11SDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :656.79 g/mol
