CAS 1386162-69-1

ML417

CAS : 1386162-69-1

ML417

Degré de pureté : ≥98%

Masse moléculaire : 379.45g/mol

Ref: 54-BUP13544

ML417

CAS : 1386162-69-1

ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).

Formule : C₂₂H₂₅N₃O₃

Degré de pureté : 98.4% - 99.42%

Couleur et forme : Solid

Masse moléculaire : 379.45

Ref: TM-T8423

ML417

CAS : 1386162-69-1

ML417 is a novel, non-peptide, high-affinity dopamine D2 receptor agonist that has been shown to be a potent functional ligand in the rat and monkey. It has been shown to increase dopamine levels in the central nervous system. ML417 also blocks the binding of [3H]spiperone to the human D2 receptor with an affinity similar to that of quinpirole (a reference high-affinity D2 receptor agonist). The compound has been shown to have clinical relevance in animal models of myocardial infarct and in behavioral assays for antipsychotic activity. In vitro studies have revealed that ML417 has biochemical properties consistent with those observed for other dopamine receptor ligands. These include binding to d2/d3 receptors and inhibition of adenylyl cyclase activity. Molecular modeling studies have demonstrated that ML417 is a high-affinity molecule for the dopamine D2 receptor with a favorable pharmacokinetic profile.

Formule : C₂₂H₂₅N₃O₃

Degré de pureté : Min. 95%

Masse moléculaire : 379.5 g/mol

Ref: 3D-LFC16269