CAS 13870-90-1

Coenzyme B12

Description :

Coenzyme B12, également connu sous le nom de méthylcobalamine, est un cofacteur vital dans divers processus biochimiques, en particulier dans le métabolisme de l'homocystéine et la synthèse de la méthionine. C'est une vitamine soluble dans l'eau appartenant au complexe des vitamines B, spécifiquement au groupe B12, qui comprend plusieurs formes de cobalamine. Caractérisé par sa structure complexe, Coenzyme B12 contient un ion cobalt en son cœur, coordonné à un anneau de corrine, et se distingue par la présence d'un groupe méthyle. Ce composé joue un rôle crucial dans le métabolisme cellulaire, en particulier dans le système nerveux central et dans la formation des globules rouges. Une carence en Coenzyme B12 peut entraîner des problèmes de santé significatifs, notamment de l'anémie et des troubles neurologiques. Il est principalement obtenu par des sources alimentaires, en particulier des produits d'origine animale, et est essentiel pour maintenir une fonction neurologique adéquate et la synthèse de l'ADN. De plus, Coenzyme B12 est souvent utilisé dans des contextes cliniques pour traiter les carences et les conditions de santé associées.

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

InChI : InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2

Code InChI : InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L

SMILES : [CH2-]([Co+3]1234[N]=5[C@@]6(C)[C@@]7([N-]1C([C@@](C)([C@H]7CC(N)=O)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]8C(O)([C@@H](N9C=[N]2C=%10C9=CC(C)=C(C)C%10)O[C@@H]8CO)[H])=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@](CC(N)=O)(C)[C@@H]%12CCC(N)=O)C(C)(C)[C@@H]%11CCC(N)=O)[H])[C@H]%13O[C@H]([C@H](O)[C@@H]%13O)N%14C=%15C(N=C%14)=C(N)N=CN%15

Synonymes :

• (5'-Deoxy-5'-adenosyl)cobamide coenzyme
• (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
• 5'-Deoxy-5'-adenosylcobalamin
• 5'-Deoxyadenosyl vitamin B12
• 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
• 5'-Deoxyadenosylcobalamin
• 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
• 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
• 5′-Deoxyadenosyl vitamin B₁₂
• Actimide
• Adenosyl B12
• Adenosyl B₁₂
• Adenosylcobalamin
• Anabasi
• Betarin
• Calomide
• Cobalamin coenzyme
• Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
• Cobalion
• Cobamamid
• Cobamamida
• Cobamamide
• Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
• Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
• Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
• Cobanzyme
• Cobatlamin S
• Cobazymase
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Coenzile
• Coenzyme B12
• Coenzyme B₁₂
• DBC
• DBC coenzyme
• Dbcc
• Deoxyadenosylcobalamin
• Dibencozide
• Dibenzcozamide
• Dimebenzcozamide
• Dolonevran
• Enzicoba
• Funacomide
• Heraclene
• Hi-Fresmin
• Hycobal
• Indusil
• Lm 176
• Represil
• Sabalamin
• Vitamin B12 coenzyme
• Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
• Vitamin B₁₂ coenzyme
• Vitamin B₁₂, Co-(5′-deoxy-5′-adenosyl) deriv.
• Xobaline
• α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
• α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
• coenzyme B12 crystalline
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• adenosyl cobalamine
• 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• DMBC COENZYME
• CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
• ADENOSYLCOBALAMINE(COENZYME B12)(P)
• cobalaminecoenzyme
• Coenzyme B
• 2
• ADENOSYLCOBALAMINE(COENZYME B12)(RG)
• 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
• Cobamamide/VitaminB12
• Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• 5’-deoxyadenosylvitaminb12
• COBAMIDE
• COBAMAMIDE/DIBENCOZIDE
• DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
• COBAMAMIDE (PYROGEN FREE)
• cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
• ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
• lm176
• ADENOSYLCOBALAMINE(COENZYME B12)(AS)
• 1
• dbccoenzyme
• COENZYME B12, >=97.0%

Adenosylcobalamin

CAS : 13870-90-1

AdoCbl is an active form of vitamin B12, a corrinoid, and cofactor for enzymes like methylmalonyl CoA mutase. Produced by select bacteria/archaea.

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Degré de pureté : 95.29% - 99.46%

Couleur et forme : Solid

Masse moléculaire : 1579.58

Ref: TM-T14128

Coenzyme B12

CAS : 13870-90-1

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Degré de pureté : (HPLC) 98.0 - 102.0 % (dried basis)

Couleur et forme : Dark red powder or crystalline powder

Masse moléculaire : 1579.58

Ref: 7W-GP8985

Cobamamide (Dibencozide, Coenzyme B12)

CAS : 13870-90-1

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Couleur et forme : Red Solid

Masse moléculaire : 1579.66

Ref: 4Z-C-161001

Cobamamide

Produit contrôlé

CAS : 13870-90-1

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Couleur et forme : Neat

Masse moléculaire : 1579.58

Ref: 04-C11692190

Cobamamide

Produit contrôlé

CAS : 13870-90-1

Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Couleur et forme : Neat

Masse moléculaire : 1579.58

Ref: TR-C633130

Coenzyme B12

CAS : 13870-90-1

Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Degré de pureté : Min. 97 Area-%

Couleur et forme : Powder

Masse moléculaire : 1,579.58 g/mol

Ref: 3D-FD65841

Cobamamide mono-Ribose13C5

Produit contrôlé

CAS : 13870-90-1

Applications Isotope labelled Cobamamide (C633130) is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Formule : C₅C₆₇H₉₉CoN₁₈O₁₇P

Couleur et forme : Neat

Masse moléculaire : 1583.537

Ref: TR-C633132

Coenzyme B12

CAS : 13870-90-1

Coenzyme B12 is a versatile building block in the production of other fine chemicals. It is an important reaction component in research and development, and can also be used as a speciality chemical. Coenzyme B12 has high quality and is used as a reagent in the synthesis of organic compounds.

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Degré de pureté : Min. 96.0 Area-%

Masse moléculaire : 1,579.58 g/mol

Ref: 3D-W-108227

Cobamamide (5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide)

CAS : 13870-90-1

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Formule : C₇₂H₁₀₀CoN₁₈O₁₇P

Couleur et forme : Powder

Masse moléculaire : 1578.65834

Ref: 45-1142195

Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)

CAS : 13870-90-1

Formule : C₇₂H₉₉CoN₁₈O₁₇P

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 1578.5738

Ref: IN-DA01CB8H