CAS 1428315-82-5

MRT-92

CAS : 1428315-82-5

MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.

Formule : C₃₃H₃₄N₄O₅

Couleur et forme : Solid

Masse moléculaire : 566.65

Ref: TM-T200033