CAS 147664-63-9

Pexiganan

Description :

Pexiganan est un peptide antimicrobien synthétique qui est principalement utilisé pour ses propriétés antibactériennes, en particulier contre les bactéries Gram-négatives. Il est dérivé de la famille des peptides magainine, qui se trouvent naturellement dans la peau de certains amphibiens. Pexiganan présente un large spectre d'activité, ce qui le rend efficace dans le traitement des infections, en particulier dans les formulations topiques pour les plaies. Le mécanisme d'action implique la perturbation des membranes cellulaires bactériennes, entraînant la lyse cellulaire. Ce peptide se caractérise par sa taille relativement petite, consistant généralement en environ 22 acides aminés, et sa nature cationique, qui améliore son interaction avec les membranes bactériennes chargées négativement. Pexiganan est également remarquable pour sa stabilité et sa résistance à la dégradation protéolytique, ce qui contribue à son efficacité dans les applications cliniques. Son développement s'est particulièrement concentré sur la préoccupation croissante concernant la résistance aux antibiotiques, fournissant une approche alternative aux thérapies antibiotiques traditionnelles. Dans l'ensemble, Pexiganan représente un candidat prometteur dans le domaine des agents antimicrobiens, en particulier pour un usage topique.

Formule : C₁₂₂H₂₁₀N₃₂O₂₂

InChI : InChI=1/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1

SMILES : CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O

Synonymes :

• Pexiganan [INN]
• Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide
• Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide
• L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan

CAS : 147664-63-9

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

Formule : C₁₂₂H₂₁₀N₃₂O₂₂

Couleur et forme : Solid

Masse moléculaire : 2477.17

Ref: TM-T73653

Pexiganan

CAS : 147664-63-9

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formule : C₁₂₂H₂₁₀N₃₂O₂₂

Masse moléculaire : 2,477.21 g/mol

Ref: 3D-PP50033

Pexiganan acetate

Produit contrôlé

CAS : 147664-63-9

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formule : C₁₂₂H₂₁₀N₃₂O₂₂•(C₂H₄O₂)x

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 2,477.18 g/mol

Ref: 3D-FP182746

Pexiganan

CAS : 147664-63-9

Pexiganan is a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formule : C₁₂₂H₂₁₀N₃₂O₂₂

Degré de pureté : Min. 95%

Masse moléculaire : 2,477.18 g/mol

Ref: 3D-FP138116