CAS 1523406-39-4

(S)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

CAS : 1523406-39-4

Formule : C₁₉H₂₁ClF₃N₅O₂

Degré de pureté : %

Couleur et forme : Solid

Masse moléculaire : 443.8505

Ref: IN-DA00ABT8

SAR405

CAS : 1523406-39-4

SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.

Formule : C₁₉H₂₁ClF₃N₅O₂

Degré de pureté : 99.42% - 99.79%

Couleur et forme : Solid

Masse moléculaire : 443.85

Ref: TM-T12831L

SAR 405

CAS : 1523406-39-4

SAR 405 is a selective inhibitor, which is synthesized chemically, targeting the phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), also known as Vps34. This inhibitor functions by specifically binding to the ATP-binding site of the kinase, thus blocking its catalytic activity. By inhibiting PIK3C3, SAR 405 disrupts phosphatidylinositol 3-phosphate (PI3P) production, a pivotal element in autophagy and endosomal trafficking processes.

Formule : C₁₉H₂₁ClF₃N₅O₂

Degré de pureté : Min. 95%

Masse moléculaire : 443.85 g/mol

Ref: 3D-YKC40639