CAS 1539296-45-1

PF-06297470

CAS : 1539296-45-1

PF-06297470 is a novel, potent and selective allosteric modulator of the metabotropic glutamate receptor type 1 (mGluR1). It has been shown to be orally active in animal models. This drug has been shown to have anti-Parkinsonian effects, which are related to its ability to inhibit glutamate release. PF-06297470 also inhibits the binding of glutamate to mGluR1 receptors, thereby inhibiting the activation of these receptors and reducing the transmission of excitatory signals in the brain. PF-06297470 binds with high affinity (Ki=0.5 nM) and selectivity to mGluR1 receptors, with no appreciable affinity for other metabotropic glutamate receptors or ion channels at concentrations up to 10 μM.

Formule : C₁₈H₁₆N₆O

Degré de pureté : Min. 95%

Masse moléculaire : 332.4 g/mol

Ref: 3D-PLC29645

PF470

CAS : 1539296-45-1

PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.

Formule : C₁₈H₁₆N₆O

Couleur et forme : Solid

Masse moléculaire : 332.36

Ref: TM-T200534