CAS 154525-25-4

uroguanyline humaine

Description :

L'uroguanyline est une hormone peptidique qui joue un rôle crucial dans la régulation de l'équilibre des fluides et des électrolytes dans le corps humain. Elle est principalement produite dans les intestins et est impliquée dans des voies de signalisation qui influencent la fonction rénale et la pression artérielle. L'uroguanyline agit en se liant aux récepteurs de la guanylate cyclase, entraînant une augmentation des niveaux intracellulaires de monophosphate de guanosine cyclique (cGMP), ce qui favorise ensuite la natriurèse (l'excrétion de sodium dans l'urine) et la diurèse (augmentation de la production d'urine). Ce peptide est structurellement similaire à la guanyline, un autre peptide intestinal, et tous deux font partie de la grande famille des peptides natriurétiques. Les effets physiologiques de l'uroguanyline incluent la modulation de la motilité gastro-intestinale et l'amélioration des mécanismes de défense de la muqueuse. Sa dysrégulation a été impliquée dans diverses conditions, y compris l'hypertension et l'insuffisance cardiaque. Le numéro CAS 154525-25-4 identifie spécifiquement ce peptide, facilitant sa reconnaissance dans la littérature scientifique et les bases de données. Dans l'ensemble, l'uroguanyline est un composant important des mécanismes homéostatiques du corps, en particulier dans la régulation des fluides.

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Synonymes :

• ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU
• Uroguanylin Topoisomer A (human)
• asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu [disulfide bridges: 4-12, 7-15]
• Uroguanylin >=90% (HPLC)
• UROGUANYLIN
• H-ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU-OH
• UGN (HUMAN)
• L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-aspartyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
• ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR- GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12, CYS7-CYS15)
• UGN (huMan)
• UROGUANYLIN (HUMAN)
• Uroguanylin (huMan)

Uroguanylin Topoisomer A (human)

CAS : 154525-25-4

Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides. This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea. Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo. Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al. (2013)).

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Degré de pureté : 92.7%

Couleur et forme : White Powder

Masse moléculaire : 1667.88

Ref: 01-4030148

Uroguanylin (human)

CAS : 154525-25-4

Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 1667.86

Ref: TM-T80067

Uroguanylin (Human)

CAS : 154525-25-4

Uroguanylin (Human) product containing the disulfide bonds: Cys4-Cys12 and Cys7-Cys15 and avaialable in the trifluoroacetate salt form. Uroguanylin is a peptide hormone that is involved in the regulation of fluid and electrolyte balance in the body. It is produced in the intestinal tract, specifically in the lining of the small intestine and colon.
Uroguanylin belongs to a family of peptides that includes guanylin and the heat-stable enterotoxins (STs).These peptides all share a similar structure and function, as they bind to and activate the guanylate cyclase-C (GC-C) receptor in intestinal cells.
Activation of GC-C by uroguanylin leads to an increase in cyclic GMP (cGMP) levels, which in turn activates a variety of downstream signaling pathways. This leads to an increase in chloride and bicarbonate secretion in the intestine, as well as an increase in intestinal fluid secretion. Uroguanylin also stimulates sodium and water reabsorption in the kidneys, leading to an increase in urine output.
Uroguanylin has been studied for its potential therapeutic applications, particularly in the treatment of gastrointestinal disorders. For example, synthetic analogs of uroguanylin are being developed as potential treatments for constipation and other disorders of intestinal motility. Additionally, uroguanylin has been shown to have anti-inflammatory properties and may be useful in the treatment of inflammatory bowel disease.

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Degré de pureté : Min. 95%

Masse moléculaire : 1,667.89 g/mol

Ref: 3D-PUG-3772-PI

Uroguanylin Isomer A (Human)

CAS : 154525-25-4

Uroguanylin is a peptide that is released by cells in the intestine. It binds to the guanylate cyclase receptor, which stimulates the production of cyclic GMP (cGMP). This leads to an increase in intestinal water and electrolyte secretion. Uroguanylin Isomer A (Human) is a high-purity peptide that can be used as a research tool for studying ligand-receptor interactions and as an inhibitor of ion channels.

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Degré de pureté : Min. 95%

Masse moléculaire : 1,667.9 g/mol

Ref: 3D-PUG-4295-S

Uroguanylin Topoisomer A (human) trifluoroacetate salt

CAS : 154525-25-4

Trifluoroacetate salt

Formule : C₆₄H₁₀₂N₁₈O₂₆S₄

Degré de pureté : Min. 95%

Masse moléculaire : 1,667.86 g/mol

Ref: 3D-FU108618