CAS 16009-13-5

Hemin

Description :

Hemin, avec le numéro CAS 16009-13-5, est un dérivé de l'hème qui joue un rôle significatif dans divers processus biochimiques. Il se caractérise par son apparence cristalline brun foncé à noir et est soluble dans des solvants organiques tels que le diméthylsulfoxyde (DMSO) et légèrement soluble dans l'eau, en particulier à pH acide. Hemin est la forme oxydée de l'hème, qui contient un ion de fer coordonné à un anneau de porphyrine. Ce composé est connu pour sa capacité à participer à des réactions redox et peut agir comme un catalyseur dans diverses voies biochimiques. Hemin est souvent utilisé dans des environnements de laboratoire pour des études liées à l'hémoglobine et à la myoglobine, ainsi que dans la synthèse d'autres composés contenant de l'hème. De plus, il a des applications en médecine, en particulier dans le traitement de certaines porphyries, où il aide à réguler la synthèse de l'hème. Sa stabilité et sa réactivité en font un composé précieux tant dans les contextes de recherche que cliniques.

Formule : C₃₄H₃₀ClFeN₄O₄·2H

InChI : InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;;

Code InChI : InChIKey=BTIJJDXEELBZFS-KKXYAJQKSA-K

SMILES : [Cl-][Fe+3]123[N-]4C5=CC6=[N]1C(=CC=7[N-]2C(C=C8[N]3=C(C=C4C(C)=C5CCC([O-])=O)C(C=C)=C8C)=C(C=C)C7C)C(C)=C6CCC([O-])=O.[H+]

Synonymes :

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron
• Chlorohemin
• Chloroprotoferriheme
• Chloroprotohemin
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-
• Ferric hemin
• Ferriheme
• Ferriheme chloride
• Ferriporphyrin chloride
• Ferriprotoporphyrin
• Ferriprotoporphyrin IX
• Ferriprotoporphyrin IX chloride
• Haemin
• Hemin
• Hemin IX
• Hemin chloride
• Hemina
• Hemine
• Iron(III) protoporphyrin chloride
• Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-
• Kjb 003
• Panhematin
• Protoferriheme
• Protohemin
• Protohemin IX
• Protohemin chloride
• Teichmann's crystals
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-
• Alkaline Hematin D-575
• UNII-743LRP9S7N
• AI3-18784
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-
• Ferrihaem
• NSC 122707
• Teichmanns crystals
• CCRIS 7061

Hemin (porcine), 97+%

CAS : 16009-13-5

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addit

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : 97+%

Couleur et forme : Dark purple or brown to black, Crystals or powder or crystalline powder

Masse moléculaire : 651.95

Ref: 02-A11165

Hemin

CAS : 16009-13-5

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 651.9403

Ref: IN-DA00HYL2

Hemin, 95%

CAS : 16009-13-5

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : ≥ 95.0%

Couleur et forme : Dark blue or dark green to brown-black powder

Masse moléculaire : 651.95

Ref: 7W-GE0624

Hemin bovine

CAS : 16009-13-5

Hemin bovine

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : 97%

Masse moléculaire : 651.95g/mol

Ref: 54-BI4570

Hemin

CAS : 16009-13-5

Hemin

Degré de pureté : ≥95%

Masse moléculaire : 651.94g/mol

Ref: 54-BUP18540

Hemin porcine

CAS : 16009-13-5

Hemin porcine

Formule : C₃₄H₃₂ClFeN₄O₄

Couleur et forme : Dark Blue Powder

Masse moléculaire : 651.94g/mol

Ref: 54-BIH1004

Hemin

CAS : 16009-13-5

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : >95%

Couleur et forme : Dark Blue

Masse moléculaire : 651.94

Ref: FT-H651-9

Hemin

CAS : 16009-13-5

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : >95.0%(T)

Couleur et forme : Dark green to Dark purple to Black powder to crystal

Masse moléculaire : 651.95

Ref: 3B-H0008

Hemin, 98%

CAS : 16009-13-5

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : ≥ 98%

Couleur et forme : Dark blue to brown-black powder

Masse moléculaire : 651.95

Ref: 7W-GE9985

Hemin

CAS : 16009-13-5

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : 97.169% - 99.59%

Couleur et forme : Dark Purple Crystalline Powder

Masse moléculaire : 651.94

Ref: TM-T5515

Hemin

CAS : 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : Min. 97 Area-%

Couleur et forme : Powder

Masse moléculaire : 651.94 g/mol

Ref: 3D-FH16318

Hemin

CAS : 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : Min. 97.0 Area-%

Masse moléculaire : 651.94 g/mol

Ref: 3D-H-1701

Hemin

CAS : 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formule : C₃₄H₃₂ClFeN₄O₄

Degré de pureté : 98.0 To 100.0 Area-%

Couleur et forme : Powder

Masse moléculaire : 651.94 g/mol

Ref: 3D-XH181795

Hemin Chloride (Technical grade)

CAS : 16009-13-5

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

Formule : C₃₄H₃₂ClFeN₄O₄

Couleur et forme : Neat

Masse moléculaire : 651.94

Ref: TR-H245648

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

CAS : 16009-13-5

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

Formule : Fe(C₃₄H₃₂N₄O₄)Cl

Degré de pureté : min. 95%

Couleur et forme : black xtl.

Masse moléculaire : 651.95

Ref: 08-26-1480

Hemin Chloride cryst. ex. Porcine extrapure, 98%

CAS : 16009-13-5

Formule : C₃₄H₃₂CIFeN₄O₄

Degré de pureté : min. 98%

Couleur et forme : Dark brownish black to dark blue to grey, Crystalline powder

Masse moléculaire : 651.96

Ref: SR-98457

Hemin Chloride cryst. ex. Bovine extrapure, 98%

CAS : 16009-13-5

Formule : C₃₄H₃₂CIFeN₄O₄

Degré de pureté : min. 98 %

Couleur et forme : Dark brownish black, Crystalline powder

Masse moléculaire : 651.96

Ref: SR-78372

Hemin

CAS : 16009-13-5

Degré de pureté : 98%

Masse moléculaire : 616.18

Ref: 10-F556533

Hemin-d6

Produit contrôlé

CAS : 16009-13-5

Formule : C₃₄D₆H₂₆ClFeN₄O₄

Couleur et forme : Neat

Masse moléculaire : 657.977

Ref: TR-H245647