CAS 1627731-61-6

ZOLEDRONIC ACID IMPURITY B CRS

CAS : 1627731-61-6

ZOLEDRONIC ACID IMPURITY B CRS

Ref: 41-Y0002027

Zoledronic Acid Related Compound B (1-Hydroxy-2-[1-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium-3-yl]-1-phosphonoethylphosphonate)

CAS : 1627731-61-6

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure nesoi

Formule : C₇H₁₆N₂O₁₄P₄

Couleur et forme : White Powder

Masse moléculaire : 475.9552

Ref: 45-1724849

1,3-Bis(2-hydroxy-2,2-diphosphonoethyl)-imidazolium Soidum Salt (1:7)(Zoledronic Acid Impurity)

Produit contrôlé

CAS : 1627731-61-6, 1632236-60-2

Applications 1,3-Bis(2-hydroxy-2,2-diphosphonoethyl)-imidazolium Soidum Salt (1:7), ( is an impurity of Zolendronic acid (trihydrate: Z623501), a biphosphonate that is used for the management of osteoporosis and the treatment of bone metastases from various types of cancers.
References Kohno, N., et al.: J. Clin. Oncol., 23, 3314 (2005); Reid, I., et al.: New Engl. J. Med., 346, 653 (2002); Rosen. L., et al.: Cancer J., 7, 377 (2000)

Formule : C₇H₉N₂Na₇O₁₄P₄

Couleur et forme : Neat

Masse moléculaire : 629.97

Ref: TR-B443840

Zoledronic acid

CAS : 1627731-61-6

Zoledronic acid is a bisphosphonate that inhibits bone resorption by binding to the hydroxyapatite crystals, thereby preventing the dissolution of bone mineral. It also has anti-tumor and anti-metastatic effects. Zoledronic acid has been shown to inhibit tumor growth in animal models and enhance antitumor activity in combination with other agents, such as docetaxel. It also induces apoptosis by inhibiting the activation of caspases and the production of tumor necrosis factor-α (TNFα) by macrophages.

Formule : C₇H₁₆N₂O₁₄P₄

Degré de pureté : Min. 95%

Masse moléculaire : 476.1 g/mol

Ref: 3D-CQC73161