CAS 163913-87-9

fragment de peptide de glycoprotéine oligodendrocytaire de myéline 35-55 rat, souris

Description :

Le fragment peptidique 35-55 de la glycoprotéine oligodendrocytaire de myéline (MOG) est un peptide synthétique dérivé de la glycoprotéine oligodendrocytaire de myéline, qui est un composant significatif de la gaine de myéline dans le système nerveux central. Ce peptide est souvent utilisé dans des recherches liées à la neuroimmunologie et à la sclérose en plaques, car il joue un rôle dans la réponse immunitaire et les processus de démyélinisation. Le numéro CAS 163913-87-9 identifie ce fragment peptidique spécifique, qui consiste en une séquence d'acides aminés capable de déclencher une réponse immunitaire dans des modèles expérimentaux, en particulier chez les rats et les souris. Les caractéristiques de ce peptide incluent sa capacité à se lier à des récepteurs spécifiques sur les cellules immunitaires, influençant potentiellement l'activation et la prolifération des cellules T. De plus, il est souvent utilisé dans des études pour comprendre les mécanismes des maladies auto-immunes et développer des stratégies thérapeutiques. Sa stabilité, sa solubilité et son activité biologique sont des facteurs critiques que les chercheurs prennent en compte lors de l'utilisation de ce peptide dans des contextes expérimentaux.

Synonymes :

• MOG 35-55 amide

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, Mouse

CAS : 163913-87-9

For cellular and molecular biology applications

Formule : C₁₁₈H₁₇₇N₃₅O₂₉S

Masse moléculaire : 2582.0

Ref: 02-J66557

MOG (Rat, Mouse, 35-55)

CAS : 163913-87-9

Amino acids 35-55 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide.
MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS).
As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (35-55) product can be used to induce these disease states in animal models.
One-Letter Formula: MEVGWYRSPFSRVVHLYRNGK

Formule : C₁₁₈H₁₇₇N₃₅O₂₉S

Degré de pureté : Min. 95%

Masse moléculaire : 2,581.95 g/mol

Ref: 3D-PMG-3660-PI

MOG (35-55) acid Mouse, Rat

CAS : 163913-87-9

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has a free carboxylic acid at the C-terminus, an amide version is also available in our catalogue.

Formule : C₁₁₈H₁₇₇N₃₅O₂₉S

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 2,581.95 g/mol

Ref: 3D-CRB1000205