CAS 1646198-75-5

Tri-b-GalNAcAc3-6-aminohexyl-NHCbz

CAS : 1646198-75-5

Tri-b-GalNAc-6-aminohexyl-NHCbz is the peracetylated form with a protected terminal amino group (NHCbz). It is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.

Formule : C₉₃H₁₄₅N₁₁O₃₉

Degré de pureté : Min. 95 Area-%

Masse moléculaire : 2,041.2 g/mol

Ref: 3D-MT184523