CAS 1648909-73-2

Bis-imidazole phenol idh1 inhibitor

CAS : 1648909-73-2

Bis-imidazole phenol IDH1 inhibitor is a small-molecule therapeutic, which is a novel compound synthesized to specifically target mutant forms of isocitrate dehydrogenase 1 (IDH1). It operates by binding to the mutant IDH1 enzyme and inhibiting its aberrant function, which involves converting alpha-ketoglutarate to an oncometabolite, 2-hydroxyglutarate (2-HG). This conversion leads to epigenetic changes that drive the tumorigenesis process.

Formule : C₂₂H₃₀N₄O

Degré de pureté : Min. 95%

Masse moléculaire : 366.5 g/mol

Ref: 3D-YQC90973

Mutant IDH1-IN-3

CAS : 1648909-73-2

Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.

Formule : C₂₂H₃₀N₄O

Couleur et forme : Solid

Masse moléculaire : 366.5

Ref: TM-T204372