CAS 1678416-36-8

(Des-Glu²²)-Amyloid β-Protein (1-40)

CAS : 1678416-36-8

The Osaka mutation was the first deletion-type mutation to be identified in APP and Aβ. The Aβ E22delta mutant is more resistant to degradation by two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. Synthetic mutant Aβ showed unusual aggregation properties with enhanced oligomerization but no fibrillization. It also inhibited hippocampal long-term potentiation more efficiently than wild-type Aβ. A transgenic mouse model containing APP with the E693delta mutation has been developed. APP(OSK)-Tg mice exhibit intraneuronal Aβ E22delta oligomers and memory impairment as early as eight months of age.

Formule : C₁₈₉H₂₈₈N₅₂O₅₅S

Degré de pureté : >91%

Couleur et forme : White Powder

Masse moléculaire : 4200.75

Ref: 01-4091431

(Des-Glu²²)-Amyloid β-Protein (1-40)

CAS : 1678416-36-8

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formule : C₁₈₉H₂₈₈N₅₂O₅₅S

Masse moléculaire : 4,200.75 g/mol

Ref: 3D-PP50600

(Des-Glu22)-Amyloid β-Protein (1-40) trifluoroacetate

CAS : 1678416-36-8

The Aβ E22delta mutant (Osaka mutation) is more resistant to degradation by two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme.  It also shows unusual aggregation properties with enhanced oligomerization but no fibrilization.

Formule : C₁₈₉H₂₈₈N₅₂O₅₅S

Degré de pureté : Min. 95 Area-%

Couleur et forme : Powder

Masse moléculaire : 4,200.69 g/mol

Ref: 3D-FD110119