CAS 169332-61-0
:acétyl-asp-glu-val-asp-7-amido-4-*méthylcoumarine
Description :
L'acétyl-asp-glu-val-asp-7-amido-4-méthylcoumarine, communément appelé substrat peptidique, est un composé synthétique souvent utilisé dans la recherche biochimique, en particulier dans les études impliquant des protéases et l'activité enzymatique. Ce composé présente une structure peptidique composée de quatre acides aminés : acide aspartique (Asp), acide glutamique (Glu) et valine (Val), liés ensemble dans une séquence spécifique. La présence du groupe 7-amido-4-méthylcoumarine sert de groupe rapporteur fluorescent, permettant le suivi des réactions enzymatiques par des mesures de fluorescence. Cette caractéristique le rend particulièrement précieux dans les tests pour les enzymes protéolytiques, où la coupure de la liaison peptidique libère le signal fluorescent. Le composé est généralement soluble dans des solvants organiques et présente une stabilité dans des conditions de laboratoire standard. Sa conception permet une spécificité dans les interactions enzyme-substrat, ce qui en fait un outil utile tant dans la recherche fondamentale qu'appliquée en biochimie et biologie moléculaire.
Formule :C30H37N5O13
Synonymes :- Ac-Asp-Glu-Val-Asp-AMC
- Ac-Devd-Amc
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8 produits concernés.
Ac-Asp-Glu-Val-Asp-AMC
CAS :A continuous fluorometric assay employing Ac-DEVD-AMC has been developed for the measurement of caspase-3, a cysteine protease also called apopain, Yama or CPP-32. The design of this substrate Ac-DEVD-AMC was based on the substrate motif that has been used successfully with caspase-1, using the poly(ADP-ribose) polymerase cleavage site P₁-P₄ tetrapeptide.Formule :C30H37N5O13Degré de pureté :97.3%Couleur et forme :White Crystalline PowderMasse moléculaire :675.65Ac-Asp-Glu-Val-Asp-AMC ammonium salt
CAS :Formule :C30H37N5O13Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :675.6405N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
CAS :Formule :C30H37N5O13Degré de pureté :(HPLC) ≥ 95.0%Couleur et forme :Conflicting attributes definedMasse moléculaire :675.64Ac-DEVD-AMC
CAS :<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Formule :C30H37N5O13Degré de pureté :98.20%Couleur et forme :White PowderMasse moléculaire :675.64Ac-Asp-Glu-Val-Asp-AMC ammonium salt
CAS :<p>Ac-Asp-Glu-Val-Asp-AMC ammonium salt is a small molecule that is used as a tool to study apoptosis in vitro. Ac-Asp-Glu-Val-Asp-AMC ammonium salt induces apoptosis by blocking the mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytoplasm. This drug also induces activation of caspase 3, which initiates the cascade of events leading to cell death. Ac-Asp-Glu-Val-Asp-AMC ammonium salt has been shown to have an antiangiogenic effect on hl60 cells. This effect may be due to its ability to inhibit expression of survivin, a protein that protects cells from apoptosis. The efficacy of this drug in an experimental model has been shown to be dependent on toll like receptor (TLR) signaling pathways and mitochondrial function.br></p>Formule :C30H37N5O13•NH3Degré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :692.67 g/molAc-Tyr-Val-Gly
CAS :<p>Ac-Tyr-Val-Gly is a mitochondrial protein that regulates mitochondrial functions and is involved in the regulation of apoptosis. Ac-Tyr-Val-Gly interacts with nuclear DNA and regulates transcription, translation, and replication. Ac-Tyr-Val-Gly has been shown to be toxic to liver cells; however, it has been shown to have no effect on neuronal death or apoptosis pathway. These effects may be due to its ability to induce proteolytic activity in neurons and its ability to activate proapoptotic proteins such as Bax.</p>Formule :C30H37N5O13Degré de pureté :Min. 95%Masse moléculaire :675.64 g/molAc-Asp-Glu-Val-Asp-AMC
CAS :<p>Ac-Asp-Glu-Val-Asp-AMC is an ion channel activator. It binds to the receptor site of the ligand, which causes a conformational change in the protein that leads to the opening of the ion channel. Ac-Asp-Glu-Val-Asp-AMC is a peptide with a molecular weight of 927.6 and is soluble in water. This product has been shown to be stable under various conditions and can be used as research tool or pharmacological agent. Ac-Asp-Glu-Val-Asp-AMC is also an antibody that binds to an epitope on human CD8 protein and can be used for cell biology studies, such as activation and inhibition of these proteins.</p>Formule :C30H37N5O13Degré de pureté :Min. 95%Masse moléculaire :675.64 g/mol
