CAS 171228-49-2
:Posaconazole
Description :
Posaconazole est un agent antifongique triazolé principalement utilisé pour la prévention et le traitement des infections fongiques, en particulier chez les patients immunodéprimés. Il présente un large spectre d'activité contre divers champignons, y compris les espèces de Candida et d'Aspergillus. La structure chimique de Posaconazole comporte un anneau triazolé, qui est crucial pour son mécanisme d'action, car il inhibe l'enzyme lanostérol 14α-déméthylase, perturbant la synthèse de l'ergostérol dans les membranes cellulaires fongiques. Cela entraîne une augmentation de la perméabilité membranaire et, en fin de compte, la mort cellulaire. Posaconazole se caractérise par sa solubilité relativement faible dans l'eau, ce qui peut affecter sa biodisponibilité ; cependant, il est disponible sous diverses formulations, y compris des suspensions orales et des comprimés à libération prolongée. Le médicament est métabolisé principalement dans le foie, et sa pharmacocinétique peut être influencée par des facteurs tels que l'apport alimentaire et les médicaments concomitants. Les effets secondaires courants peuvent inclure des troubles gastro-intestinaux et des élévations des enzymes hépatiques. Dans l'ensemble, Posaconazole est une option thérapeutique vitale dans la gestion des infections fongiques invasives, en particulier chez les populations à haut risque.
Formule :C37H42F2N8O4
InChI :InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
Code InChI :InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES :C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Synonymes :- (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
- <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
- Noxafil
- Posaconazole SP
- Posaconazole for research
- Sch 56592
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-
- Voir plus de synonymes
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19 produits concernés.
Posaconazole
CAS :Formule :C37H42F2N8O4Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :700.79Posaconazole
CAS :Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormule :C37H42F2N8O4Couleur et forme :White PowderMasse moléculaire :700.329714-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS :Formule :C37H42F2N8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.7774Posaconazole-d5
CAS :Formule :C37H37D5F2N8O4Couleur et forme :White To Off-White SolidMasse moléculaire :705.82Posaconazole
CAS :Formule :C37H42F2N8O4Degré de pureté :98.0 - 102.0 % (dry basis)Couleur et forme :White to off-white powderMasse moléculaire :700.78Posaconazole
CAS :Formule :C37H42F2N8O4Couleur et forme :White To Off-White SolidMasse moléculaire :700.79Posaconazole
CAS :Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).Formule :C37H42F2N8O4Degré de pureté :99.72% - >99.99%Couleur et forme :White SolidMasse moléculaire :700.78Posaconazole Impurity 92
CAS :Formule :C14H15F2N3O2Couleur et forme :White To Off-White SolidMasse moléculaire :295.29Posaconazole - Bio-X ™
CAS :Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.Formule :C37H42F2N8O4Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :700.78 g/molPosaconazole - Form I
CAS :Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.Formule :C37H42F2N8O4Degré de pureté :Min. 95%Masse moléculaire :700.78 g/molPosaconazole - Form III
CAS :Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formule :C37H42F2N8O4Degré de pureté :Min. 95%Masse moléculaire :700.78 g/molPosaconazole Monodesfluoro
CAS :Produit contrôléFormule :C21H22FN3O4SCouleur et forme :NeatMasse moléculaire :431.481Posaconazole (Ethyl-d5)
CAS :Produit contrôléFormule :C37D5H37F2N8O4Couleur et forme :NeatMasse moléculaire :705.808Posaconazole
CAS :Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formule :C37H42F2N8O4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :700.78 g/mol
![4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KV.jpg&w=3840&q=75)
