CAS 1802068-51-4

UNI418

CAS : 1802068-51-4

UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).

Formule : C₂₂H₁₆N₆

Couleur et forme : Solid

Masse moléculaire : 364.40

Ref: TM-T200240