CAS 18162-48-6

chlorure de tert-butyldiméthylsilyle

Description :

chlorure de tert-butyldiméthylsilyle (chlorure de TBDMS) est un composé organosiliconé caractérisé par son utilisation comme groupe protecteur pour les alcools et les amines dans la synthèse organique. Il présente un groupe tert-butyle attaché à une partie diméthylsilyle, ce qui améliore sa stabilité et sa réactivité. Le composé est généralement un liquide incolore à jaune pâle avec une odeur piquante, et il est connu pour sa capacité à former des éthers silyles stables lors de la réaction avec des alcools. Le chlorure de TBDMS est sensible à l'humidité et doit être manipulé dans des conditions anhydres pour éviter l'hydrolyse, ce qui peut conduire à la formation d'alcools silyles. Il est soluble dans des solvants organiques tels que le dichlorométhane et l'éther, mais est insoluble dans l'eau. Le composé est couramment utilisé dans la synthèse de molécules organiques complexes, en particulier dans le domaine de la chimie médicinale et de la synthèse de produits naturels, en raison de son efficacité à protéger sélectivement les groupes fonctionnels lors de réactions en plusieurs étapes. Des précautions de sécurité appropriées doivent être prises lors de la manipulation du chlorure de TBDMS, car il peut être irritant pour la peau et le système respiratoire.

Formule : C₆H₁₅ClSi

InChI : InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3

Code InChI : InChIKey=BCNZYOJHNLTNEZ-UHFFFAOYSA-N

SMILES : C([Si](C)(C)Cl)(C)(C)C

Synonymes :

• (1,1-Dimethylethyl)dimethylsilyl chloride
• 2-(Chlorodimethylsilyl)-2-methylpropane
• 2-[4-(TertButyldimethylsilanyloxy)phenyl] chloride
• Chloro(1,1-dimethylethyl)dimethylsilane
• Chloro-tert-butyldimethylsilane
• Chlorodimethyl-tert-butylsilane
• Dimethyl(1,1-dimethylethyl)chlorosilane
• Dimethyl-tert-butylchlorosilane
• Dimethyl-tert-butylsilyl chloride
• Ls 1190
• Silane, T-Butyl-Dimethylchloro-
• Silane, chloro-tert-butyldimethyl-
• T-Butyldimethylchlorosilane
• TBDMS chloride
• TBDMS-Cl
• TBSCl
• Terc-Butilclorodimetilsilano
• Tert-Butyldimethylchlorosilane
• tert-Butyl(dimethyl)silane chloride
• tert-Butylchlordimethylsilan
• tert-Butylchlorodimethylsilane
• tert-Butyldimethylsilyl chloride
• (1-chloro-2-methylpropan-2-yl)(dimethyl)silane
• Silane, chloro(1,1-dimethylethyl)dimethyl-
• Tert-Butyl Dimethyl Silyl Chloride
• TBDMSCL
• Tertiary butyldimethylchlorosilane
• Tert-butyl-dimethyl chlorosilance
• Tert-Butyl Dimethylchlorosilane

tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]

CAS : 18162-48-6

Formule : C₆H₁₅ClSi

Degré de pureté : >98.0%(GC)

Couleur et forme : White to Almost white powder to crystal

Masse moléculaire : 150.72

Ref: 3B-B0995

tert-Butyldimethylchlorosilane, 50% w/w in toluene

CAS : 18162-48-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formule : C₆H₁₅ClSi

Couleur et forme : Clear colorless, Liquid

Masse moléculaire : 150.72

Ref: 02-B21286

tert-Butyldimethylchlorosilane, 97%

CAS : 18162-48-6

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines

Formule : C₆H₁₅ClSi

Degré de pureté : 97%

Couleur et forme : Colorless to white, Crystals or powder or crystalline powder or lumps or fused solid

Masse moléculaire : 150.72

Ref: 02-A13064

tert-Butyldimethylchlorosilane

CAS : 18162-48-6

Formule : C₆H₁₅ClSi

Degré de pureté : 95%

Couleur et forme : Solid

Masse moléculaire : 150.7218

Ref: IN-DA0035NH

tert-Butyldimethylsilyl chloride

CAS : 18162-48-6

tert-Butyldimethylsilyl chloride

Formule : C₆H₁₅ClSi

Degré de pureté : ≥95%

Couleur et forme : white crystals

Masse moléculaire : 150.72179g/mol

Ref: 54-OR019066

tert-Butyldimethylchlorosilane

CAS : 18162-48-6

Formule : C₆H₁₅ClSi

Degré de pureté : ≥ 99.0%

Couleur et forme : White crystals

Masse moléculaire : 150.73

Ref: 7W-GK9215

tert-Butyldimethylchlorosilane

CAS : 18162-48-6

S03300 - tert-Butyldimethylchlorosilane

Formule : C₆H₁₅ClSi

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 150.72

Ref: 10-S03300

tert-Butyldimethylsilyl chloride, 50% solution in toluene

CAS : 18162-48-6

tert-Butyldimethylsilyl chloride, 50% solution in toluene

Degré de pureté : ≥95%

Couleur et forme : Colourless Liquid

Masse moléculaire : 150.72g/mol

Ref: 54-OR40716

tert-Butyldimethylsilyl Chloride

CAS : 18162-48-6

Applications Used to protect alcohols during organic synthesis.
References Shen, H., et al.: J. Med. Chem., 53, 2666 (2010), Qiang, L., et al.: Bioorg. Med. Chem. Lett., 20, 836 (2010),

Formule : C₆H₁₅ClSi

Couleur et forme : White Solid

Masse moléculaire : 150.72

Ref: TR-B691080

tert-Butyldimethylsilyl chloride

CAS : 18162-48-6

Tert-butyldimethylsilyl chloride is a silicon-containing compound that is used to prepare the tert-butyl group, which is an important part of many organic compounds. Tert-butyldimethylsilyl chloride reacts with trifluoroacetic acid to form hydrogen bonds. It can also react with hydrochloric acid to form a tert-butyl chloride, which is soluble in water and hydrolyzes in human serum. Tert-butyldimethylsilyl chloride has been used for the synthesis of carbohydrates and fatty acids. It has been used as a sample preparation agent for gas chromatography mass spectrometry and high performance liquid chromatography. The reaction solution can be prepared by reacting tert-butyldimethylsilyl chloride with an alcohol or carboxylic acid in the presence of base at low temperature. Tert-butyldimethylsilyl chloride can be synthesized by reacting

Formule : C₆H₁₅ClSi

Degré de pureté : Min. 95 Area-%

Couleur et forme : Colorless Powder

Masse moléculaire : 150.73 g/mol

Ref: 3D-FB07718

t-BUTYLDIMETHYLCHLOROSILANE

CAS : 18162-48-6

Trialkylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
tert-Butyldimethylchlorosilane; TBS-Cl; Chlorodimethyl-t-butylsilane; tert-Butylchlorodimethylsilane; Chloro(1,1-dimethylethyl)dimethylsilane
Excellent for 1° and 2° alcoholsSilylation catalyzed by imidazoleBlocking agent widely used in prostaglandin synthesisStable to many reagentsCan be selectively cleaved in presence of acetate, THP and benzyl ethers among othersUsed for the protection of alcohols, amines, thiols, lactams, and carboxylic acidsClean NMR characteristics of protecting groupSilylation reagent - derivatives resistant to Grignards, alkyl lithium compounds, etcFacile removal with flouride ion sourcesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Formule : C₆H₁₅ClSi

Degré de pureté : 97%

Couleur et forme : Translucent Solid

Masse moléculaire : 150.72

Ref: 3H-SIB1935.0

t-Butyldimethylchlorosilane, min. 97%

CAS : 18162-48-6

t-Butyldimethylchlorosilane, min. 97%

Formule : (CH₃)₃CSi(CH₃)₂Cl

Degré de pureté : min. 97%

Couleur et forme : white pwdr.

Masse moléculaire : 150.70

Ref: 08-14-1775

tert-Butyldimethylsilyl Chloride (TBDMS.Cl) extrapure, 98%

CAS : 18162-48-6

Formule : C₆H₁₅ClSi

Degré de pureté : min. 98%

Couleur et forme : White, Hygroscopic compound, Clear, Colourless

Masse moléculaire : 150.73

Ref: SR-39227