CAS 2026-58-6

α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol (E/Z mixture)

Produit contrôlé

CAS : 2026-58-6

Applications α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol is an intermediate in the synthesis of Norbormide (N661150), a rodenticide that acts as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
References Rennison, D., et al.: Bioorg. Med. Chem. 15, 2963 (2007);

Formule : C₂₉H₂₂N₂O

Couleur et forme : Neat

Masse moléculaire : 414.5

Ref: TR-P321585

α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol

CAS : 2026-58-6

α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol is a synthetic compound that is used as an impurity standard in the research and development of drugs. It is also used as a custom synthesis drug product to create a high purity, pharmacopeia grade drug. α-Phenyl-α-[3-(phenyl-2-pyridinylmethylene)-2,4-cyclopentadien-1-yl]-2-pyridinemethanol has been shown to be an active metabolite for the treatment of hypertension. Metabolism studies have shown that this drug is subject to oxidative metabolism by cytochrome P450 enzymes with subsequent oxidation of the pyridine ring. The resulting metabolite can then bind to DNA and inhibit transcription and replication.

Formule : C₂₉H₂₂N₂O

Degré de pureté : Min. 95%

Masse moléculaire : 414.5 g/mol

Ref: 3D-CAA02658