CAS 20449-79-0

Mélittine

Description :

Mélittine est un peptide dérivé du venin des abeilles (Apis mellifera) et est connu pour sa puissante activité biologique. Il est composé de 26 acides aminés et a un poids moléculaire d'environ 2846 Da. Mélittine se caractérise par sa nature amphipathique, ce qui lui permet d'interagir avec les membranes lipidiques, entraînant une disruption de la membrane et une lyse cellulaire. Cette propriété en fait un sujet d'intérêt dans divers domaines, y compris l'immunologie et la recherche sur le cancer, car il présente des activités antimicrobiennes et anticancéreuses. De plus, Mélittine peut induire une inflammation et a été étudié pour ses applications thérapeutiques potentielles, bien que ses effets cytotoxiques nécessitent une attention particulière dans l'utilisation médicale. Le peptide est soluble dans l'eau et présente une structure hélicoïdale dans les environnements membranaires, contribuant à sa capacité à former des pores dans les bicouches lipidiques. Dans l'ensemble, Mélittine sert de modèle précieux pour comprendre les interactions peptide-membrane et a un potentiel pour développer de nouveaux agents thérapeutiques.

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

InChI : InChI=1/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1

Synonymes :

• H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
• Melittin From Bee Venom Sequencing*Grade
• Beevenommelittin

Melittin

CAS : 20449-79-0

Synthetic melittin, the main component of the honeybee venom. The amphiphilic nature of this antimicrobial peptide makes it a excellent model compound for monitoring lipid-protein interactions in membranes. Adade et al. observed that melittin peptide could kill Trypanosoma cruzi parasites by inducing different cell death pathways.

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : 98.5%

Couleur et forme : White

Masse moléculaire : 2846.5

Ref: 01-4030808

Melittin

CAS : 20449-79-0

Melittin

Degré de pureté : 98%

Masse moléculaire : 2,846.46g/mol

Ref: 54-BIM0170

Melittin

CAS : 20449-79-0

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : ≥ 97.0%

Couleur et forme : White to faint yellow or faint tan powder

Masse moléculaire : 2846.46

Ref: 7W-GK3910

Melittin

CAS : 20449-79-0

Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : 98.37% - 99.92%

Couleur et forme : Solid

Masse moléculaire : 2846.46

Ref: TM-TP1299

Melittin - 95%

CAS : 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 2,846.47 g/mol

Ref: 3D-FM10065

Melittin

CAS : 20449-79-0

Melittin is a 26-residue peptide originally isolated from venom of the European honeybee. Melittin is a cationic, hemolytic peptide from honey bee venom. Melittin lowers the surface tension at the plasma membrane and causes cell lysis. Melittin exhibits potent anti-inflammatory and antimicrobial activity. Melittin has been extensively used as a model peptide for observing membrane lipid-protein interactions.

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Couleur et forme : Powder

Masse moléculaire : 2,846.47 g/mol

Ref: 3D-CRB1000015

Melittin, 70%

CAS : 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 2,846.46 g/mol

Ref: 3D-XM176021

Melittin

CAS : 20449-79-0

Melittin is a major component of bee venom that has been shown to have antibacterial efficacy against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. It also demonstrates anti-viral activity, for example it inhibits human immunodeficiency virus and herpes simplex virus. Furthermore it can be used in the treatment of inflammatory-related illnesses due to it inhibiting the phospholipase A2 enzyme. In addition to this Melittin's abaility to inhibit inflammatory mediators such as nitric oxide and cyclooxygenase-2 aids in the treatment of inflammatory diseases. As a result of Melittin having the capabilities of attacking lipid membranes and it surpressing COX-2 mRNA expression it can also be used in the treatment of tumours. The bound form of melittin is not toxic to mammalian cells, but it is toxic when it is released into the cell cytoplasm. Melittin has been shown to inhibit transcriptional regulation and locomotor activity in mice. This may be due to its ability to bind DNA, preventing transcription and translation of certain genes. Lastly It has strong hemolytic activity and been seen to increase insulin secretion via depolarization of pancreatic beta-cells. Melittin is a diverse peptide which can be used ina whole spectrum of research and therapeutic areas.

Formule : C₁₃₁H₂₂₉N₃₉O₃₁

Degré de pureté : Min. 95%

Masse moléculaire : 2,846.47 g/mol

Ref: 3D-TOX-70001-PI