CAS 2099014-23-8

MJ04

CAS : 2099014-23-8

MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).

Formule : C₂₀H₁₆FN₅

Couleur et forme : Solid

Masse moléculaire : 345.37

Ref: TM-T87974