CAS 215258-13-2

FR167344 free base

CAS : 215258-13-2

FR167344 free base: oral, nonpeptide B2 bradykinin receptor antagonist, high-affinity (IC50: 65 nM), no B1 affinity.

Formule : C₃₀H₂₈BrCl₂N₅O₄

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 673.38

Ref: TM-T15347

FR167344

CAS : 215258-13-2

FR167344 is a b2 receptor antagonist that inhibits the binding of the ligands bradykinin and thromboxane A2 to their receptors. It has been shown to be effective in the treatment of inflammatory diseases such as pancreatitis, and also for reducing leukotriene synthesis. The pharmacokinetics of FR167344 have been studied in rats, mice, and healthy volunteers. It is absorbed from the gastrointestinal tract and eliminated by liver metabolism. The drug is eliminated mainly through renal excretion of unchanged drug, with less than 1% metabolized by the liver.
FR167344 has been shown to inhibit binding of bradykinin to its receptor in cell membrane preparations from human epidermoid carcinoma (A431) cells and lung fibroblasts, with a maximal response at concentrations between 0.1-10 µM.

Formule : C₃₀H₂₈BrCl₂N₅O₄

Degré de pureté : Min. 95%

Masse moléculaire : 673.4 g/mol

Ref: 3D-QIA25813