CAS 221877-54-9

Zotarolimus

Description :

Zotarolimus, avec le numéro CAS 221877-54-9, est un composé macrolide synthétique qui appartient à la classe des agents immunosuppresseurs. Il est principalement utilisé dans le domaine médical comme revêtement de stent libérant des médicaments pour prévenir la resténose dans les artères coronaires après une angioplastie. Zotarolimus fonctionne en inhibant la prolifération des cellules musculaires lisses et en modulant la réponse immunitaire, ce qui aide à réduire le risque de blocage artériel. Le composé présente un mécanisme d'action similaire à celui du sirolimus, ciblant la voie de la cible mammifère de la rapamycine (mTOR), qui est cruciale pour la croissance cellulaire et le métabolisme. Zotarolimus se caractérise par sa nature lipophile, ce qui améliore sa capacité à adhérer aux surfaces des stents et à se libérer progressivement au fil du temps. Sa pharmacocinétique implique une demi-vie relativement longue, permettant des effets thérapeutiques soutenus. Des profils de sécurité et d'efficacité ont été établis par le biais d'études cliniques, en faisant un outil précieux en cardiologie interventionnelle. Cependant, comme tous les médicaments, il peut avoir des effets secondaires et des contre-indications potentielles qui doivent être prises en compte dans la pratique clinique.

Formule :C₅₂H₇₉N₅O₁₂

InChI :InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

Code InChI :InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES :O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

Synonymes :

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
42-(1-Tetrazolyl)rapamycin
A 179578
Abt 578
Endeavor
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Resolute
Unii-H4gxr80ize
Zotarolimus
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ZotaroliMus(ABT-578)
Zotarolimus, &gt
ZotaroliMus, >90%
ZOTAROLIMUS USP/EP/BP
ZOTAROLIMUS Impurities
ZotaroliMus API
42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
CS-1162
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Voir plus de synonymes

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Tri par prix ascendantTri par prix descendantPuretés inférieures en premierPuretés supérieures en premierLivraison estimée la plus rapide en premier

Degré de pureté (%)

100

7 produits concernés.

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Zotarolimus
CAS :
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Formule :C₅₂H₇₉N₅O₁₂
Degré de pureté :95%
Couleur et forme :Solid
Masse moléculaire :966.2100
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Zotarolimus
CAS :
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Zotarolimus
Degré de pureté :≥95%
Masse moléculaire :966.21g/mol
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Zotarolimus
CAS :
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Formule :C₅₂H₇₉N₅O₁₂
Couleur et forme :Off-White Solid
Masse moléculaire :966.23
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Zotarolimus
CAS :
- 221877-54-9
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
Formule :C₅₂H₇₉N₅O₁₂
Degré de pureté :95% - 98.01%
Couleur et forme :Solid
Masse moléculaire :966.21
Ref: TM-T6033
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Zotarolimus-d3
CAS :
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Formule :C₅₂H₇₆D₃N₅O₁₂
Masse moléculaire :969.23
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Zotarolimus
CAS :
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<p>Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.</p>
Formule :C₅₂H₇₉N₅O₁₂
Degré de pureté :Min. 95%
Couleur et forme :White Powder
Masse moléculaire :966.21 g/mol
Ref: 3D-FZ28788
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25mg
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Zotarolimus-d3, >90% (contains d0)
Produit contrôléVeuillez noter qu'il s'agit d'un produit contrôlé dans certains pays et qu'il doit être traité conformément aux réglementations en vigueur. Cela peut entraîner des frais et des documents supplémentaires.
CAS :
- 221877-54-9
Formule :C₅₂D₃H₇₆N₅O₁₂
Couleur et forme :Neat
Masse moléculaire :969.229
Ref: TR-Z700802
2500µg
1.509,00€
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