CAS 2319882-48-7

Lx7101 hydrochloride

CAS : 2319882-48-7

Lx7101 is a dimethylcarbamate that has been shown to be a potent inhibitor of the enzyme glutathione reductase, which is involved in the detoxification of reactive oxygen species. Lx7101 inhibits the synthesis of glutathione, which can lead to oxidative stress and cell death.

Formule : C₂₃H₃₀ClN₇O₃

Degré de pureté : Min. 95%

Masse moléculaire : 488 g/mol

Ref: 3D-USD88248

LX7101 hydrochloride

CAS : 2319882-48-7

LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.

Formule : C₂₃H₂₉N₇O₃HCl

Couleur et forme : Solid

Masse moléculaire : 488

Ref: TM-T85304