CAS 2334434-49-8

PF-06815345

CAS : 2334434-49-8

PF-06815345 is a kinetic convertase inhibitor that binds to the active site of the enzyme, inhibiting its activity. This compound has been shown to inhibit human low-density lipoprotein (LDL) cholesterol production in vitro and reduce plasma LDL-cholesterol levels in vivo. The mechanism of action of PF-06815345 is not clear, but it may be due to inhibition of statin catalysis, which leads to a decrease in the level of functional LDL receptors on liver cells. The drug also inhibits the activity of serine proteases such as subtilisin and kexin type enzymes. In addition, PF-06815345 has been shown to be an organocatalyst for low-temperature aldehyde synthesis, with tetrazole as a key intermediate. It is also used for treatment of cardiovascular diseases such as high blood pressure and elevated levels of low density lipoprotein cholesterol (LDL-C).

Formule : C₂₇H₂₉ClFN₉O₄·HCl

Degré de pureté : Min. 95%

Masse moléculaire : 634.49 g/mol

Ref: 3D-JTD43449

PF-06815345 hydrochloride

CAS : 2334434-49-8

PF-06815345 HCl is an oral, potent PCSK9 inhibitor, IC50 13.4 μM, lowers PCSK9 in mice.

Formule : C₂₇H₃₀Cl₂FN₉O₄

Couleur et forme : Solid

Masse moléculaire : 634.49

Ref: TM-T72221