CAS 2414909-94-5

4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide

CAS : 2414909-94-5

Formule : C₁₉H₁₆N₆O

Degré de pureté : %

Couleur et forme : Solid

Masse moléculaire : 344.3699

Ref: IN-DA01KKND

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

CAS : 2414909-94-5

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

Degré de pureté : 98+%

Masse moléculaire : 344.37g/mol

Ref: 54-OR1024325

RET V804M-IN-1

CAS : 2414909-94-5

RET V804M-IN-1

Degré de pureté : ≥95%

Masse moléculaire : 344.37g/mol

Ref: 54-BUP12576

RET V804M-IN-1

CAS : 2414909-94-5

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Formule : C₁₉H₁₆N₆O

Degré de pureté : 97.94% - 99.62%

Couleur et forme : Solid

Masse moléculaire : 344.37

Ref: TM-T8467

RET V804M-IN-1

CAS : 2414909-94-5

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Formule : C₁₉H₁₆N₆O

Degré de pureté : Min. 97 Area-%

Couleur et forme : White Powder

Masse moléculaire : 344.37 g/mol

Ref: 3D-EP176311