CAS 24305-27-9

Hormone de libération de la thyrotropine

Description :

L'hormone de libération de la thyréostimuline (TRH), également connu sous le nom de Hormone de libération de la thyrotropine, est une hormone tripeptidique composée de trois acides aminés : acide pyroglutamique, histidine et proline. Il joue un rôle crucial dans la régulation de la fonction thyroïdienne en stimulant la libération de l'hormone thyréostimulante (TSH) de la glande pituitaire antérieure. La TRH est synthétisée dans l'hypothalamus et est impliquée dans l'axe hypothalamo-hypophysaire-thyroïdien, influençant les processus métaboliques et l'homéostasie énergétique. Le numéro CAS 24305-27-9 identifie spécifiquement ce peptide, qui se trouve généralement sous forme solide ou lyophilisée pour des applications de recherche et thérapeutiques. La TRH est soluble dans l'eau et peut être administrée par diverses voies, y compris par injection intraveineuse ou sous-cutanée. Son activité biologique est médiée par des récepteurs spécifiques dans la glande pituitaire, entraînant des effets en aval sur la production d'hormones thyroïdiennes. De plus, la TRH a été étudiée pour ses rôles potentiels dans diverses conditions physiologiques et pathologiques, y compris ses effets sur l'humeur et les réponses au stress.

Formule : C₁₆H₂₂N₆O₄

InChI : InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

Code InChI : InChIKey=XNSAINXGIQZQOO-SRVKXCTJSA-N

SMILES : C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3

Synonymes :

• (Pyro)-<span class="text-smallcaps">L</smallcap>-glutamic acid-<smallcap>L</smallcap>-histidine-<smallcap>L</span>-proline-NH₂
• (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2
• 252: PN: WO2010033207 SEQID: 378 claimed protein
• 5-Oxo-<span class="text-smallcaps">L</smallcap>-prolyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• 83: PN: US20090175821 PAGE: 403 claimed protein
• <span class="text-smallcaps">L</smallcap>-Prolinamide, 5-oxo-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-histidyl-
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">L</smallcap>-Pyroglutamyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-proline amide
• Abbott 38579
• Antepan
• Fda 1725
• L-Pyroglutamyl-L-histidyl-L-prolinamide
• L-Pyroglutamyl-L-histidyl-L-proline amide
• Lopremone
• Prem
• Protirelin
• Protirelina
• Protireline
• Relefact TRH
• Rifathyroin
• Rifotironin
• Ro 8-6270/9
• Stimu TSH
• Synthetic TRF
• Synthetic TRH
• Synthetic TSH-releasing factor
• Synthetic TSH-releasing hormone
• Synthetic thyrotropin-releasing factor
• Synthetic thyrotropin-releasing hormone
• TRF
• TRH
• TSH-releasing factor
• TSH-releasing hormone
• Thypinone
• Thyrefact
• Thyroid releasing hormone
• Thyroid-stimulating hormone-releasing factor
• Thyroliberin
• Thyrotropic hormone-releasing factor
• Thyrotropic hormone-releasing hormone
• Thyrotropic releasing hormone
• Thyrotropic-releasing factor
• Thyrotropin-releasing factor
• Thyrotropin-releasing hormone
• Tsh-Rf
• L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-

Thyrotropin-Releasing Hormone

CAS : 24305-27-9

Thyrotropin-Releasing Hormone

Formule : C₁₆H₂₂N₆O₄

Couleur et forme : White, Lyophilized powder

Masse moléculaire : 362.38

Ref: 02-J62120

TRH

CAS : 24305-27-9

TRH exhibits a variety of biological effects, when injected into humans or animals. Its physiological role appears to be the stimulation of thyrotropin (TSH) and prolactin (PRL) release from the anterior pituitary. Though it was first identified in the hypothalamus as a regulator of the pituitary-thyroid axis, TRH was detected as well by Luo et al. in pancreatic β-cells co-localized with insulin. Application of the hormone reverted hyperglycemia in rats. Moreover, TRH plays an important role in the control of human hair-growth and hair follicle pigmentation.

Formule : C₁₆H₂₂N₆O₄

Degré de pureté : 98.6%

Couleur et forme : Whitish Powder

Masse moléculaire : 362.39

Ref: 01-4038214

PROTIRELIN CRS

CAS : 24305-27-9

PROTIRELIN CRS

Formule : C₁₆H₂₂N₆O₄

Masse moléculaire : 362.3837

Ref: 41-P3760000

Protirelin

CAS : 24305-27-9

Protirelin

Degré de pureté : ≥98%

Masse moléculaire : 362.38g/mol

Ref: 54-BUP06401

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

CAS : 24305-27-9

L-Pyroglutamyl-L-Histidyl-L-Prolinamide

Degré de pureté : 98%

Masse moléculaire : 362.38g/mol

Ref: 54-OR1026190

Thyrotropin releasing hormone

CAS : 24305-27-9

Formule : C₁₆H₂₂N₆O₄

Masse moléculaire : 362.38

Ref: 7W-GL4561

Protirelin

CAS : 24305-27-9

Formule : C₁₆H₂₂N₆O₄

Masse moléculaire : 362.39

Ref: 4Z-PP-357001

Protirelin

CAS : 24305-27-9

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

Formule : C₁₆H₂₂N₆O₄

Degré de pureté : 99.76%

Couleur et forme : White Or Almost White Powder

Masse moléculaire : 362.38

Ref: TM-T6956

Protirelin

CAS : 24305-27-9

Couleur et forme : Neat

Ref: 86-MM3358.00

Protirelin

CAS : 24305-27-9

Formule : C₁₆H₂₂N₆O₄

Degré de pureté : 95%~99%

Couleur et forme : White to Off-white Powder

Masse moléculaire : 362.38

Ref: BP-BPPG055

Thyrotropin-Releasing Hormone

Produit contrôlé

CAS : 24305-27-9

Applications Thyrotropin-Releasing Hormone is a hypothalamic hypophysiotropic neuropeptide, which has the ability to stimulate the release of thyroid-stimulating hormone in mammals. It is proven that Thyrotropin-Releasing Hormone can be used to accelerate wound healing.
References Kanasaki, H., et al.: Neuropeptides., 54, 73 (2015); Nie, C., et al.: J. Surg. Res., 189, 364 (2014);

Formule : C₁₆H₂₂N₆O₄

Couleur et forme : Off-White

Masse moléculaire : 362.38

Ref: TR-T413510

L-Pyroglutamyl-L-histidyl-L-prolinamide

CAS : 24305-27-9

L-Pyroglutamyl-L-histidyl-L-prolinamide (PGC) is a pyrrolidine that is used for the treatment of neurologic disorders. It has been shown to be effective in treating depression and a number of other neurologic disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. PGC has also been shown to have an antidepressant effect in women with depression who are pregnant or have recently given birth. In addition, it has been found to be clinically effective in the treatment of symptoms associated with Parkinson’s Disease. PGC is not absorbed into the bloodstream and must be injected directly into muscle tissue or fat cells in order to produce its therapeutic effects.

Formule : C₁₆H₂₂N₆O₄

Degré de pureté : Min. 95%

Couleur et forme : White Powder

Masse moléculaire : 362.38 g/mol

Ref: 3D-FP33965

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS : 24305-27-9

Thyrotropin releasing hormone (TRH) is a peptide that is produced in the hypothalamus. It has various functions, including being an activator of thyroid stimulating hormone (TSH) and releasing growth hormone from the anterior pituitary gland. TRH also has anti-inflammatory effects and is used as a research tool in cell biology. TRH binds to receptors on cells and can activate ion channels, which causes an influx of calcium ions into cells. This leads to the activation of protein kinases, which are important in cell signaling pathways. TRH also interacts with other proteins, such as receptor tyrosine kinases and G-protein coupled receptors.

Formule : C₁₆H₂₂N₆O₄

Degré de pureté : Min. 95%

Masse moléculaire : 362.38 g/mol

Ref: 3D-PTR-4011-V

Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)

CAS : 24305-27-9

Thyrotropin Releasing Hormone (TRH) is a hormone that stimulates the release of thyroid hormones. TRH has been used to diagnose and treat conditions such as autoimmune diseases, infectious diseases, and thyroid disease. It is also used in the treatment of patients with hypothyroidism who are not responding to levothyroxine therapy. TRH is administered intravenously or intramuscularly. This drug is primarily used for diagnostic purposes in women who have symptoms of hyperthyroidism but normal serum levels of TSH and thyroxine levels. TRH administration can result in a rise in serum prolactin levels, which may be useful for diagnosis of the condition hyperprolactinemia.

Formule : C₁₆H₂₂N₆O₄•H₂O

Degré de pureté : Min. 95%

Masse moléculaire : 380.4 g/mol

Ref: 3D-PTR-4011