CAS 25316-40-9
:Chlorhydrate de doxorubicine
Description :
Chlorhydrate de doxorubicine est un antibiotique anthracycline couramment utilisé en chimiothérapie contre le cancer. Il se caractérise par sa couleur rouge vif et est connu pour son activité antitumorale puissante. Le composé agit en intercalant l'ADN, inhibant ainsi la synthèse des acides nucléiques et perturbant la réplication des cellules cancéreuses. La doxorubicine est soluble dans l'eau et présente un profil de solubilité dépendant du pH, ce qui est important pour sa formulation et son administration. Son mécanisme d'action implique également la génération de radicaux libres, contribuant à ses effets cytotoxiques. Cependant, l'utilisation de la doxorubicine est associée à plusieurs effets secondaires, y compris la cardiotoxicité, qui limite sa dose cumulative. Elle est généralement administrée par voie intraveineuse et est souvent utilisée en combinaison avec d'autres agents chimiothérapeutiques pour améliorer l'efficacité contre diverses malignités, y compris le cancer du sein, la leucémie et les lymphomes. En raison de ses avantages thérapeutiques significatifs et des risques potentiels, une surveillance et une gestion attentives sont essentielles pendant le traitement.
Formule :C27H29NO11·ClH
InChI :InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Code InChI :InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES :OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Synonymes :- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- ADM hydrochloride
- ADR
- Adriablastina CS
- Adriacin
- Adriamycin
- Adriamycin, hydrochloride
- Adriblastin
- Adriblastina
- Adriblastina RD
- Adrosal
- Ameisu hydrochloride
- Caelyx pegylated liposomal
- DOX HCl
- Doxolipad
- Doxorubicin, HCl
- Doxorubicin-LANS
- Doxorubicin-TEVA
- Doxourbicin HCl
- Fi 106
- Fi 6804
- Hydroxydaunorubicin hydrochloride
- Lipo-Dox
- Lipodox
- Myocet liposomal
- Voir plus de synonymes
Trier par
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27 produits concernés.
Doxorubicin Hydrochloride
CAS :Formule :C27H29NO11·HClDegré de pureté :>95.0%(HPLC)Couleur et forme :Light yellow to Brown powder to crystalMasse moléculaire :579.98Doxorubicin hydrochloride
CAS :<p>Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.</p>Formule :C27H30ClNO11Couleur et forme :Crystalline powder or granular, Red to orangeMasse moléculaire :579.98DOXORUBICIN HYDROCHLORIDE CRS
CAS :<p>DOXORUBICIN HYDROCHLORIDE CRS</p>Formule :C27H29NO11Couleur et forme :Crystalline Powder. Orange. Red. Powder.Masse moléculaire :543.5193Doxorubicin hydrochloride
CAS :Doxorubicin hydrochlorideFormule :C27H29NO11HClDegré de pureté :99.0%Couleur et forme :Orange To Dark RedMasse moléculaire :579.15074DOXORUBICIN HYDROCHLORIDE RS
CAS :<p>DOXORUBICIN HYDROCHLORIDE RS</p>Formule :C27H29NO11Masse moléculaire :543.5193Doxorubicin Hydrochloride
CAS :<p>Antibiotics nesoi</p>Formule :C27H29NO11·ClHCouleur et forme :Red Orange Crystalline Powder Amorphous PowderMasse moléculaire :579.15074(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS :Formule :C27H30ClNO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :579.9802Doxorubicin hydrochloride
CAS :<p>Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).</p>Formule :C27H29NO11·HClDegré de pureté :98% - 99.52%Couleur et forme :Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Masse moléculaire :579.99Doxorubicin hydrochloride
CAS :<p>Doxorubicin hydrochloride</p>Degré de pureté :≥98%Masse moléculaire :579.99g/molDoxorubicin hydrochloride
CAS :<p>Doxorubicin hydrochloride</p>Formule :C27H29NO11·ClHDegré de pureté :99%Couleur et forme : orange red crystalline powderMasse moléculaire :579.98019g/molDoxorubicin hydrochloride, USP grade
CAS :Formule :C27H29NO11·HClDegré de pureté :≥ 98.0% (anhydrous, solvent-free)Couleur et forme :Orange-red to red crystalline powderMasse moléculaire :579.99Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS :Formule :C27H29NO11·HClCouleur et forme :Red SolidMasse moléculaire :543.53 36.46Doxorubicin hydrochloride, 98%
CAS :Formule :C27H29NO11·HClDegré de pureté :(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Couleur et forme :Orange-red to red crystalline powderMasse moléculaire :579.99Doxorubicin Hydrochloride
CAS :Produit contrôléFormule :C27H29NO11·ClHCouleur et forme :NeatMasse moléculaire :579.98Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS :Formule :C13C22H26D3NO11·HClMasse moléculaire :547.56 36.45Doxorubicin Hydrochloride
CAS :<p>Stability Hygroscopic, Light Sensitive<br>Applications Doxorubicin Hydrochloride is an antineoplastic agent.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);<br></p>Formule :C27H29NO11·ClHCouleur et forme :NeatMasse moléculaire :579.98Doxorubicin hydrochloride
CAS :<p>Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.</p>Formule :C27H29NO11•HClDegré de pureté :Min. 95%Masse moléculaire :579.98 g/molDoxorubicin hydrochloride - Bio-X ™
CAS :<p>Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.</p>Formule :C27H29NO11•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :579.98 g/molDoxorubicin HCl
CAS :<p>Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.</p>Formule :C27H29NO11·HClDegré de pureté :Min. 98 Area-%Couleur et forme :Red PowderMasse moléculaire :579.98 g/molDoxorubicin hydrochloride
CAS :Formule :C27H30ClNO11Degré de pureté :95.0%Couleur et forme :Solid, Crystalline Powder or Granules or PowderMasse moléculaire :579.98Doxorubicin hydrochloride, 10 mg/ml aqueous solution
CAS :<p>Doxorubicin hydrochloride, 10 mg/ml aqueous solution, is a chemotherapeutic agent, which is an anthracycline antibiotic derived from the bacterium *Streptomyces peucetius var. caesius*. Its mode of action involves the intercalation into DNA, disrupting the replication and transcription processes crucial for cancer cell proliferation. Additionally, it generates free radicals that cause further damage to cellular structures and inhibit topoisomerase II, thereby preventing the unwinding of DNA necessary for replication.</p>Formule :C27H29NO11•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :579.98 g/molDes-[(4-Amino-2,3,6-trideoxy-hexapyranosyl)oxy)-1-methyl] 2-Carboxylate Doxorubicin
CAS :Produit contrôléFormule :C20H12O7Couleur et forme :NeatMasse moléculaire :364.305
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