CAS 2566733-45-5

HLB-0532259

CAS : 2566733-45-5

HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)

Formule : C₄₀H₄₄N₈O₇

Couleur et forme : Solid

Masse moléculaire : 748.827

Ref: TM-T204754