CAS 26305-03-3

pepstatine A ~120'000 U/mg

Description :

La pepstatine A est un inhibiteur puissant et sélectif des aspartyl protéases, en particulier de la rénine et de la pepsine, et est dérivée de la fermentation de certaines espèces de la bactérie *Streptomyces*. Elle se caractérise par sa structure unique, qui comprend un squelette peptidique avec une séquence spécifique lui permettant de se lier efficacement aux sites actifs des enzymes cibles, inhibant ainsi leur activité. La substance a un poids moléculaire d'environ 1 000 Da et est souvent utilisée dans la recherche biochimique pour étudier les processus protéolytiques et la cinétique enzymatique. La pepstatine A présente une haute spécificité et affinité pour les aspartyl protéases, ce qui en fait un outil précieux tant dans la recherche fondamentale qu'appliquée, y compris les études liées à la digestion des protéines et à la régulation. Son efficacité est souvent quantifiée en unités d'inhibition, telles que "120 000 U/mg", indiquant sa puissance. De plus, il est important de manipuler la pepstatine A avec précaution, car elle peut avoir des effets biologiques, et des conditions de stockage appropriées sont nécessaires pour maintenir sa stabilité et son activité.

Formule : C₃₄H₆₃N₅O₉

InChI : InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1

Synonymes :

• Pepstatin A
• pepstatin A from microbial source
• Pepstatin (microbial product)
• Isovaleryl-Val-Val-Sta-Ala-Sta-OH
• N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
• (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
• Pepstatin

Pepstatin A

CAS : 26305-03-3

Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : > 99%

Couleur et forme : White Powder

Masse moléculaire : 685.9

Ref: 01-4031136

Pepstatin

CAS : 26305-03-3

Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : 96.74% - 99.94%

Couleur et forme : Solid

Masse moléculaire : 685.89

Ref: TM-T3695

L-Alaninamide,N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-

CAS : 26305-03-3

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : 75%

Couleur et forme : Solid

Masse moléculaire : 685.8921

Ref: IN-DA00I50B

Pepstatin A

CAS : 26305-03-3

Pepstatin A

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : By hplc: 98.2% (220 nm) (Typical Value in Batch COA)

Couleur et forme : white to off white powder

Masse moléculaire : 685.89212g/mol

Ref: 54-BIMI2205

Pepstatin

CAS : 26305-03-3

Pepstatin

Degré de pureté : ≥95%

Masse moléculaire : 685.89g/mol

Ref: 54-BUP16261

Pepstatin A

CAS : 26305-03-3

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : >90.0%(HPLC)

Couleur et forme : White to Light yellow powder to crystal

Masse moléculaire : 685.90

Ref: 3B-P3041

Pepstatin A

CAS : 26305-03-3

Formule : C₃₄H₆₃N₅O₉

Masse moléculaire : 685.90

Ref: 4Z-P-470001

Pepstatin A

CAS : 26305-03-3

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : ≥ 98.0%

Couleur et forme : White to off-white powder

Masse moléculaire : 685.90

Ref: 7W-GE3524

Pepstatin A (Purity Higher than 90% by HPLC)

CAS : 26305-03-3

Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A has

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : Higher Than 90% By Hplc)

Masse moléculaire : 685.89 g/mol

Ref: 3D-IPA-4397

Pepstatin A (Synthetic)

CAS : 26305-03-3

Pepstatin A is a natural product that has been synthesized for use as an inhibitor of proteolytic enzymes. It inhibits the activity of a wide range of proteases and is used in vitro to study the biochemical properties of these enzymes. Pepstatin A inhibits the activity of many important proteases, including those involved in infectious diseases, such as HIV and hepatitis C virus. Pepstatin A binds to the active site on serine proteases, blocking access by their substrates and thereby inhibiting enzyme activity. The binding site is highly conserved among different types of serine protease, with approximately 90% homology between trypsin and chymotrypsin. The inhibitory mechanism involves a specific interaction between pepstatin A's hydrophobic side chain and the catalytic triad residues His57, Asp102, and Ser195 in trypsin or His57, Asp102, and Ser188 in chymotrypsin.

Formule : C₃₄H₆₃N₅O₉

Degré de pureté : Min. 95%

Masse moléculaire : 685.89 g/mol

Ref: 3D-IPA-3998-PI

Pepstatin A

CAS : 26305-03-3

Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.

Masse moléculaire : 685.89 g/mol

Ref: 3D-CRB1001649